What Can I Compare With The Pep Nation Lab Comparison Tool?

Any research-grade compound in the library can be placed side by side - up to four at a time. The tool compares mechanism of action, molecular target, evidence tier, molecular weight, amino acid sequence, reported half-life, and what each compound has been studied for, all drawn from referenced monographs.

What Does The Evidence Tier Mean?

The evidence tier reflects how extensively a compound has been studied in the referenced literature, from early preclinical signals through to compounds with human clinical data. It is a research-quality signal only, never a safety or efficacy endorsement.

How Are "X vs Y" Comparison Pages Built?

Each comparison page is generated from the same referenced compound database - a genuine side-by-side of mechanism, identity, pharmacokinetics, and evidence, plus data-derived key differences. They are curated, not auto-generated thin pages.

Is Any Of This Medical Or Dosing Advice?

No. Every comparison is for in vitro laboratory research use only. Nothing here is medical advice, a treatment recommendation, or dosing guidance, and no product is for human or animal consumption.

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Select Up To Four Compounds To Review Their Evidence, Targets, And Handling Side By Side.
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2/4

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TesamorelinA+97

HGH FragmentB+88

Top Pick: TesamorelinTap to see full verdict & analysis

Tesamorelin

0/100

Grade A+

Leads in evidence strength

Evidence

Safety

Science

Coverage

Handling

Depth

Unique: Performance & Muscle, Joint & Bone Support

HGH Fragment 176-191

0/100

Grade B+

Leads in safety profile

Evidence

Safety

Science

Coverage

Handling

Depth

Research Profile Radar - hover axes for details

Tesamorelin

HGH Fragment 176-191

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Attribute	Tesamorelin A+	HGH Fragment 176-191 B+
Research Summary	Tesamorelin is the only growth hormone booster specifically proven to target and melt away hard, stubborn belly fat (visceral fat). It was literally FDA-approved just for this purpose.	This is literally just the fat-burning piece of human growth hormone cut off from the rest. Because it is only the fat-burning piece, it burns fat rapidly without causing muscles to grow or affecting your blood sugar.
Studied For	HIV-associated lipodystrophy (FDA approved)Hepatic fat / NAFLD researchCognition research in aging/HIVGH deficiencyBody composition improvementVisceral adipose reductionLiver fat reductionGH axis stimulationIGF-1 elevationCardiovascular lipid profile improvementCognitive decline in aging HIV+ populationAnti-aging via GH axisNon-alcoholic fatty liver diseaseLean mass supportvisceral fat reductionbelly fatHIV lipodystrophymuscle growthbody compositionlipid profile improvementcognitive function	Lipolysis / fat lossAdipose reductionVisceral fat reductionBody composition improvementSubcutaneous fat burningFat oxidationAnti-obesity researchWeight managementMetabolic rate enhancementFat-loss peptide researchAbdominal fat researchBeta-3 adrenergic lipolysisLean mass preservation during fat lossGH-fragment weight research
Research Areas	Performance & MuscleMetabolicWeight Management & Fat LossJoint & Bone SupportCognitive	MetabolicWeight Management & Fat Loss
Best Stacked With	ipamorelincjc-1295-no-dacl-carnitinebac-water	aod9604l-carnitinelipo-cbac-water
Overview
Category	Muscle Growth & Performance	Muscle Growth & Performance
Compound Class	Synthetic GHRH analog with trans-3-hexenoic acid modification at N-terminus; FDA-approved for HIV lipodystrophy	Synthetic fragment of HGH C-terminus (residues 176-191)
Molecular Target	GHRH receptor (GHRHR) on pituitary somatotrophs; GH/IGF-1 axis stimulation; preferential visceral fat metabolism	Beta-3 adrenergic receptors; stimulates lipolysis without GH receptor binding; no IGF-1 elevation
Aliases / AKA	EgriftaEgrifta SVTH9507Tesamorelin acetateTrans-3-hexenoic acid GHRHModified GHRH analog Egrifta	HGH FragAOD FragmentFrag 176-191HGH FragmentFragment 176-191HGH 176-191
Parent Compound	Growth hormone releasing hormone	Human growth hormone
Molecular Weight	5135.9 Da	1817.1 Da
Amino Acid Sequence	`hGHRH(1-44) with trans-3-hexenoyl`	`16-aa C-terminal lipolytic fragment of human growth hormone (residues 176-191)`
CAS Number	218949-48-5	66004-57-7
Year Discovered	Not Listed	Not Listed
Pro-Angiogenic	No	No
GLP-1 Class	No	No
Purity	Not Listed	Not Listed
Identity
Evidence Tier
Risk Level
PubMed Citations	125 Moderate	23 Sparse
Clinical Trials	1010 Active	Not Listed
Regulatory Status	FDA-approved (Egrifta) for HIV lipodystrophy; WADA S2.	Not FDA-approved; research chemical; WADA-banned.
Evidence & Regulatory
Half-Life	~26-38 minutes	~3 minutes
Typical Frequency	Not Listed	Not Listed
Administration Route	Injection Only	Injection Only
Mechanism / PK	Not Listed	Not Listed
Reported Findings	Strong human randomized trials show roughly 15 to 18 percent visceral-fat reduction over 26 weeks with reduced triglycerides and reduced liver fat. It is FDA-approved for HIV-associated lipodystrophy.	Obese-mouse studies show reduced weight and increased fat oxidation. Human evidence for the fragment is minimal; most human data come from the related AOD9604, which was ultimately not significant.
Side Effects Noted	Joint pain, injection-site reactions, peripheral edema, paresthesia, reduced glucose tolerance and elevated IGF-1.	Limited formal human safety data; mainly injection-site reactions in unregulated use; long-term safety uncharacterized.
Warnings	Contraindicated in active malignancy, pituitary disorders, and pregnancy; monitor IGF-1 and glucose. Benefit reverses on discontinuation. WADA-prohibited (needs a therapeutic-use exemption).	Not approved; human efficacy unproven; grey-market identity and purity are a major limitation. WADA-banned. Research use only.
Pharmacology
Form	lyophilized	lyophilized
Diluent	sterile water	bacteriostatic water; slow, no foaming
Storage Temp	per formulation (room temp or refrigerated); follow label	-20C, dark
Light Sensitive	Yes	Yes
Freeze / Thaw	avoid	avoid
Handling Notes	Daily subcutaneous; improper reconstitution causes aggregation.	Disulfide loop is oxidation-sensitive.
Reconstituted Shelf Life	1 Days Refrigerated	28 Days Refrigerated
Handling & Storage

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