Thymalin
Also Known As: Thymus polypeptide bioregulator, Thymalin peptide, Thymus bioregulator, Thymus extract bioregulator, Khavinson thymus peptide, Thymulin analog, Immune restoration bioregulator, Thymic polypeptide thymalin, Calf thymus extract peptide, Immunomodulatory thymalin, thymus extract, thymic bioregulator
Thymalin is a research-grade Polypeptide thymic bioregulator derived from calf thymus tissue targeting T-lymphocyte differentiation and maturation studied in Anti-Aging & Longevity research. It is supplied strictly for in vitro laboratory research use only - not for human or animal consumption, and not FDA-approved.
Evidence Tier: Research Compound - No approved human use; sold for laboratory research only.
A thymus-derived immune-modulating preparation studied mainly in older Russian literature for immune restoration.
At A Glance
| Category | Anti-Aging & Longevity |
|---|---|
| Compound Class | Polypeptide thymic bioregulator derived from calf thymus tissue |
| Molecular Target | T-lymphocyte differentiation and maturation; thymic hormones (thymosin, thymopoietin analog); IL-2 / IFN-gamma restoration |
| Molecular Weight | Heterogeneous mixture; roughly 80 to 90 percent of components fall between 600 and 6000 Da |
| Amino Acid Sequence | Calf thymus low-molecular-weight polypeptide complex; not a single molecule. Constituent dipeptides include Glu-Trp (Thymogen / Oglufanide, CAS 38101-59-6) and Lys-Glu (Vilon, CAS 45234-02-4). |
| CAS Number | 131183-11-4 (Thymalin, calf thymus polypeptide complex) |
| Half-Life | ~15 minutes |
| WADA Status | not_listed |
| Evidence Tier | Research Compound |
Mechanism Of Action
It regulates the thymus gland, stimulating the production and maturation of T-cells, ensuring the immune system can correctly identify and destroy harmful pathogens without attacking healthy cells.
Studied For
- Immunosenescence reversal
- Immune system restoration in aging
- Infection resistance enhancement
- T-cell function restoration
- Longevity via immune optimization
- Age-related immune decline
- Cancer immune surveillance research
- HIV immune support models
- Chronic infection models
- Thymus involution reversal
- Autoimmune modulation research
- Antioxidant protection
- Melatonin-thymalin longevity combination
- immune regulation
- anti-aging
- T-cell function
- longevity
- viral infections
- immune restoration
Reported Research Findings
Russian elderly-cohort studies report improved T-cell counts and, in long follow-ups, reduced infections. Largely single-lineage and older; preliminary.
Safety And Handling Notes
Reported well tolerated in Russian clinical use; no robust modern adverse-event dataset; possible immunogenicity from a tissue-extract product.
Not FDA or EMA approved; extract composition can vary by source; caution in autoimmunity. Research use only. Identity resolved 2026-08-04: Thymalin is the calf thymus polypeptide complex (CAS 131183-11-4), not a single defined molecule. Material sold as "Thymalin" that is actually the Glu-Trp dipeptide is mislabelled; that dipeptide is properly Thymogen (Oglufanide, CAS 38101-59-6), one constituent isolated from the Thymalin low-molecular-weight fraction. Confirm which material a certificate of analysis describes.
Regulatory Status
Used in Russia; not US or EU approved; research chemical.
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