PT-141 vs Kisspeptin-10: Research Comparison
A Side-By-Side Research Comparison Of PT-141 And Kisspeptin-10 - melanocortin versus kisspeptin pathways in reproductive research. This Reference Compares Mechanism, Evidence Tier, Molecular Identity, And Pharmacokinetics For Qualified Researchers. For In Vitro Laboratory Research Use Only. Not Medical Advice Or Dosing Guidance.
Side-By-Side Comparison
| PT-141 | Kisspeptin-10 | |
|---|---|---|
| Category | Sexual Health & Hormones | Sexual Health & Hormones |
| Compound Class | Cyclic heptapeptide melanocortin receptor agonist; Melanotan II analog without linear structure | Endogenous neuropeptide (KISS1 gene product fragment); GPR54/KISS1R agonist |
| Evidence Tier | Approved Drug | Investigational |
| Molecular Target | MC4R (melanocortin-4 receptor) in hypothalamus; dopaminergic sexual arousal pathway; also MC1R (minor) | GPR54 / KISS1R on GnRH neurons in hypothalamus; stimulates LH/FSH via pulsatile GnRH release |
| Molecular Weight | 1025.18 Da | 1302.5 Da |
| Amino Acid Sequence | Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys)-OH | YNWNSFGLRF-NH2 |
| CAS Number | 189691-06-3 | 374675-21-5 |
| Half-Life | ~2.7 hours | ~4 minutes |
| Studied For | Hypoactive sexual desire disorder (HSDD) in premenopausal women (FDA approved), Erectile dysfunction research (historical), Female sexual arousal disorder, Male sexual dysfunction research | Reproductive axis research, LH/FSH stimulation, Fertility treatment, GnRH pulse regulation |
About PT-141
An approved desire-disorder peptide for premenopausal women, acting in the brain.
Read The Full PT-141 MonographAbout Kisspeptin-10
A reproductive-hormone trigger peptide studied for fertility; investigational.
Read The Full Kisspeptin-10 MonographKey Differences
- Evidence tier differs: PT-141 is classified as Approved Drug; Kisspeptin-10 is classified as Investigational.
- Reported half-life differs: PT-141 at ~2.7 hours versus Kisspeptin-10 at ~4 minutes.
- Primary molecular target differs: PT-141 acts on MC4R (melanocortin-4 receptor) in hypothalamus; dopaminergic sexual arousal pathway; also MC1R (minor); Kisspeptin-10 acts on GPR54 / KISS1R on GnRH neurons in hypothalamus; stimulates LH/FSH via pulsatile GnRH release.
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This Comparison Is Provided For In Vitro Laboratory Research Use Only. Not For Human Consumption, Diagnosis, Or Treatment. See The Full Research Disclaimer.