IGF-1 LR3 vs Follistatin: Research Comparison
A Side-By-Side Research Comparison Of IGF-1 LR3 And Follistatin - direct IGF-1 signaling versus myostatin inhibition in muscle research. This Reference Compares Mechanism, Evidence Tier, Molecular Identity, And Pharmacokinetics For Qualified Researchers. For In Vitro Laboratory Research Use Only. Not Medical Advice Or Dosing Guidance.
Side-By-Side Comparison
| IGF-1 LR3 | Follistatin | |
|---|---|---|
| Category | Muscle Growth & Performance | Muscle Growth & Performance |
| Compound Class | Long-acting recombinant IGF-1 analog (Arg3 substitution, 13 N-terminal extension) | Endogenous glycoprotein / activin-binding protein (recombinant) |
| Evidence Tier | Research Compound | Preclinical |
| Molecular Target | IGF-1 receptor (IGF1R); PI3K/Akt/mTOR signaling; satellite cell proliferation; reduced IGFBP binding = extended half-life | Myostatin (GDF-8) and activin A neutralization; prevents TGF-beta superfamily inhibition of muscle growth |
| Molecular Weight | 9111 Da | 38000 Da |
| Amino Acid Sequence | 83-aa analog (Arg3 + N-terminal extension) | 344-residue glycoprotein |
| CAS Number | 946870-92-4 | not standardized |
| Half-Life | ~20-30 h | ~2 hours |
| Studied For | Muscle growth / hypertrophy, Anabolic research, GH axis signaling, Lean mass increase | Muscle hypertrophy, Myostatin inhibition, Female fertility, Lean muscle mass increase |
About IGF-1 LR3
A potent long-acting IGF-1 analog used as a lab reagent; hypoglycemia and growth risks; banned in sport.
Read The Full IGF-1 LR3 MonographAbout Follistatin
A myostatin-blocking protein studied for muscle growth, mostly via gene therapy; banned in sport.
Read The Full Follistatin MonographKey Differences
- Evidence tier differs: IGF-1 LR3 is classified as Research Compound; Follistatin is classified as Preclinical.
- Reported half-life differs: IGF-1 LR3 at ~20-30 h versus Follistatin at ~2 hours.
- Primary molecular target differs: IGF-1 LR3 acts on IGF-1 receptor (IGF1R); PI3K/Akt/mTOR signaling; satellite cell proliferation; reduced IGFBP binding = extended half-life; Follistatin acts on Myostatin (GDF-8) and activin A neutralization; prevents TGF-beta superfamily inhibition of muscle growth.
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This Comparison Is Provided For In Vitro Laboratory Research Use Only. Not For Human Consumption, Diagnosis, Or Treatment. See The Full Research Disclaimer.