Hexarelin
Also Known As: Examorelin, EP-23905, MF-6003, Hexarelin peptide, His-D-2-MeTrp-Ala-Trp-D-Phe-Lys, Growth hexapeptide, Cardioprotective GHRP, GHRP-6 analog, His6-hexarelin, Cardiovascular GH peptide, Hexarelin acetate, cardioprotective GHRP, examorelin
Hexarelin is a research-grade Synthetic hexapeptide GH secretagogue targeting GHS-R1a studied in Muscle Growth & Performance research. It is supplied strictly for in vitro laboratory research use only - not for human or animal consumption, and not FDA-approved.
Evidence Tier: Research Compound - No approved human use; sold for laboratory research only.
The most potent classic growth-hormone-releasing peptide; banned in sport.
At A Glance
| Category | Muscle Growth & Performance |
|---|---|
| Compound Class | Synthetic hexapeptide GH secretagogue (GHRP); potent ghrelin mimetic with cardiac-specific effects |
| Molecular Target | GHS-R1a (ghrelin receptor); also acts on CD36 scavenger receptor on cardiomyocytes for GH-independent cardioprotection |
| Molecular Weight | 887.05 Da |
| Amino Acid Sequence | His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2 |
| CAS Number | 140703-51-1 |
| Half-Life | ~55 minutes |
| WADA Status | prohibited |
| Evidence Tier | Research Compound |
Mechanism Of Action
It binds tightly to the ghrelin receptor in the brain and ignores the body's natural "stop" signals, resulting in an unnaturally large surge of growth hormone release.
Studied For
- GH secretagogue research
- Cardiac protection / cardioprotection
- Cytoprotection
- IGF-1 elevation
- Body composition / lean mass
- Anti-aging via GH axis
- Fat loss via GH
- Heart failure models
- Ischemia reperfusion research
- Pituitary GH function
- GHS-R independent cardiac effects
- Muscle growth research
- Bone density via GH
- Recovery and repair
- Ghrelin axis signaling
- growth hormone secretagogue
- muscle growth
- heart health
- cardiac protection
- ischemia
Reported Research Findings
Human studies show potent growth-hormone release; cardiovascular studies suggest CD36-mediated effects. Receptor desensitization with continued use is documented.
Safety And Handling Notes
Cortisol and prolactin elevation like GHRP-2; growth-hormone desensitization with continued use; flushing, headache, water retention.
Not approved; tachyphylaxis limits sustained efficacy. WADA-prohibited. Research use only.
Regulatory Status
Not FDA-approved; research chemical; WADA S2.
Full Reference Detail
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This Reference Is Provided For In Vitro Laboratory Research Use Only. Not For Human Consumption. See The Full Research Disclaimer.