Hexarelin vs Ipamorelin: Research Comparison
A Side-By-Side Research Comparison Of Hexarelin And Ipamorelin - a potent versus a highly selective ghrelin-receptor secretagogue. This Reference Compares Mechanism, Evidence Tier, Molecular Identity, And Pharmacokinetics For Qualified Researchers. For In Vitro Laboratory Research Use Only. Not Medical Advice Or Dosing Guidance.
Side-By-Side Comparison
| Hexarelin | Ipamorelin | |
|---|---|---|
| Category | Muscle Growth & Performance | Muscle Growth & Performance |
| Compound Class | Synthetic hexapeptide GH secretagogue (GHRP); potent ghrelin mimetic with cardiac-specific effects | Selective synthetic pentapeptide GH secretagogue (GHRP); minimal cortisol/prolactin side effects |
| Evidence Tier | Research Compound | Research Compound |
| Molecular Target | GHS-R1a (ghrelin receptor); also acts on CD36 scavenger receptor on cardiomyocytes for GH-independent cardioprotection | GHS-R1a (ghrelin receptor) agonist; highly selective for pituitary GH release without significant ACTH/cortisol elevation |
| Molecular Weight | 887.05 Da | 711.85 Da |
| Amino Acid Sequence | His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2 | Aib-His-D-2-Nal-D-Phe-Lys-NH2 |
| CAS Number | 140703-51-1 | 170851-70-4 |
| Half-Life | ~55 minutes | ~2 hours |
| Studied For | GH secretagogue research, Cardiac protection / cardioprotection, Cytoprotection, IGF-1 elevation | GH secretagogue research, Anti-aging / longevity via GH axis, Body composition improvement, Lean muscle gain |
About Hexarelin
The most potent classic growth-hormone-releasing peptide; banned in sport.
Read The Full Hexarelin MonographAbout Ipamorelin
A selective, clean growth-hormone-releasing peptide; banned in sport.
Read The Full Ipamorelin MonographKey Differences
- Reported half-life differs: Hexarelin at ~55 minutes versus Ipamorelin at ~2 hours.
- Primary molecular target differs: Hexarelin acts on GHS-R1a (ghrelin receptor); also acts on CD36 scavenger receptor on cardiomyocytes for GH-independent cardioprotection; Ipamorelin acts on GHS-R1a (ghrelin receptor) agonist; highly selective for pituitary GH release without significant ACTH/cortisol elevation.
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This Comparison Is Provided For In Vitro Laboratory Research Use Only. Not For Human Consumption, Diagnosis, Or Treatment. See The Full Research Disclaimer.