Ipamorelin
Also Known As: NNC 26-0161, NNC26-0161, Ipamorelin acetate, GHRP-1a analog, Selective GHRP, Ipamorelin peptide, Growth hormone secretagogue ipamorelin, IPA peptide, Aib-His-D-2-Nal-D-Phe-Lys-NH2, Pentapeptide GHS, growth hormone secretagogue, GHS, ipa
Ipamorelin is a research-grade Selective synthetic pentapeptide GH secretagogue targeting GHS-R1a studied in Muscle Growth & Performance research. It is supplied strictly for in vitro laboratory research use only - not for human or animal consumption, and not FDA-approved.
Evidence Tier: Research Compound - No approved human use; sold for laboratory research only.
A selective, clean growth-hormone-releasing peptide; banned in sport.
At A Glance
| Category | Muscle Growth & Performance |
|---|---|
| Compound Class | Selective synthetic pentapeptide GH secretagogue (GHRP); minimal cortisol/prolactin side effects |
| Molecular Target | GHS-R1a (ghrelin receptor) agonist; highly selective for pituitary GH release without significant ACTH/cortisol elevation |
| Molecular Weight | 711.85 Da |
| Amino Acid Sequence | Aib-His-D-2-Nal-D-Phe-Lys-NH2 |
| CAS Number | 170851-70-4 |
| Half-Life | ~2 hours |
| WADA Status | prohibited |
| Evidence Tier | Research Compound |
Mechanism Of Action
It is a highly selective ghrelin mimetic. It stimulates a clean pulse of growth hormone without accidentally triggering the release of cortisol (stress) or prolactin, making it incredibly well-tolerated.
Studied For
- GH secretagogue research
- Anti-aging / longevity via GH axis
- Body composition improvement
- Lean muscle gain
- Fat loss via GH
- Sleep quality / GH rhythm
- Recovery
- Bone density via GH
- IGF-1 elevation
- Pulsatile GH release simulation
- Stacked with CJC-1295 (no DAC)
- GI motility research
- Metabolic rate improvement
- Collagen synthesis via GH
- Athletic performance
- anti-aging
- muscle growth
- fat loss
- recovery
- deep sleep
- bone density
- cellular repair
- GH pulse stimulation
Reported Research Findings
Preclinical work established growth-hormone release with no rise in cortisol or prolactin. A human GI-motility program was run and discontinued for non-safety reasons.
Safety And Handling Notes
Best tolerated of the GHRPs; injection-site reactions, flushing, headache, mild water retention; limited human data.
Not approved; growth-hormone-axis risks apply with sustained use. WADA-prohibited. Research use only.
Regulatory Status
Not FDA-approved; research chemical; WADA S2.
Full Reference Detail
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This Reference Is Provided For In Vitro Laboratory Research Use Only. Not For Human Consumption. See The Full Research Disclaimer.