Ipamorelin vs Sermorelin: Research Comparison
A Side-By-Side Research Comparison Of Ipamorelin And Sermorelin - a ghrelin-receptor secretagogue versus a GHRH analog for growth-hormone research. This Reference Compares Mechanism, Evidence Tier, Molecular Identity, And Pharmacokinetics For Qualified Researchers. For In Vitro Laboratory Research Use Only. Not Medical Advice Or Dosing Guidance.
Side-By-Side Comparison
| Ipamorelin | Sermorelin | |
|---|---|---|
| Category | Muscle Growth & Performance | Muscle Growth & Performance |
| Compound Class | Selective synthetic pentapeptide GH secretagogue (GHRP); minimal cortisol/prolactin side effects | Synthetic 29-amino acid fragment of endogenous GHRH (GHRH 1-29-NH2) |
| Evidence Tier | Research Compound | Approved Drug |
| Molecular Target | GHS-R1a (ghrelin receptor) agonist; highly selective for pituitary GH release without significant ACTH/cortisol elevation | GHRH receptor (GHRHR) on anterior pituitary somatotrophs; stimulates endogenous GH gene expression and release |
| Molecular Weight | 711.85 Da | 3357.93 Da |
| Amino Acid Sequence | Aib-His-D-2-Nal-D-Phe-Lys-NH2 | GHRH(1-29) amide |
| CAS Number | 170851-70-4 | 86168-78-7 |
| Half-Life | ~2 hours | ~10-20 min |
| Studied For | GH secretagogue research, Anti-aging / longevity via GH axis, Body composition improvement, Lean muscle gain | Pituitary GH-reserve diagnostic, Pediatric GH deficiency (historical), Adult GH-axis / anti-aging research, GH secretagogue research |
About Ipamorelin
A selective, clean growth-hormone-releasing peptide; banned in sport.
Read The Full Ipamorelin MonographAbout Sermorelin
A growth-hormone-releasing hormone analog formerly approved for childhood GH deficiency; banned in sport.
Read The Full Sermorelin MonographKey Differences
- Evidence tier differs: Ipamorelin is classified as Research Compound; Sermorelin is classified as Approved Drug.
- Reported half-life differs: Ipamorelin at ~2 hours versus Sermorelin at ~10-20 min.
- Primary molecular target differs: Ipamorelin acts on GHS-R1a (ghrelin receptor) agonist; highly selective for pituitary GH release without significant ACTH/cortisol elevation; Sermorelin acts on GHRH receptor (GHRHR) on anterior pituitary somatotrophs; stimulates endogenous GH gene expression and release.
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This Comparison Is Provided For In Vitro Laboratory Research Use Only. Not For Human Consumption, Diagnosis, Or Treatment. See The Full Research Disclaimer.