IGF-1 LR3 vs Ipamorelin: Research Comparison
A Side-By-Side Research Comparison Of IGF-1 LR3 And Ipamorelin - a direct IGF-1 analog versus a growth-hormone secretagogue. This Reference Compares Mechanism, Evidence Tier, Molecular Identity, And Pharmacokinetics For Qualified Researchers. For In Vitro Laboratory Research Use Only. Not Medical Advice Or Dosing Guidance.
Side-By-Side Comparison
| IGF-1 LR3 | Ipamorelin | |
|---|---|---|
| Category | Muscle Growth & Performance | Muscle Growth & Performance |
| Compound Class | Long-acting recombinant IGF-1 analog (Arg3 substitution, 13 N-terminal extension) | Selective synthetic pentapeptide GH secretagogue (GHRP); minimal cortisol/prolactin side effects |
| Evidence Tier | Research Compound | Research Compound |
| Molecular Target | IGF-1 receptor (IGF1R); PI3K/Akt/mTOR signaling; satellite cell proliferation; reduced IGFBP binding = extended half-life | GHS-R1a (ghrelin receptor) agonist; highly selective for pituitary GH release without significant ACTH/cortisol elevation |
| Molecular Weight | 9111 Da | 711.85 Da |
| Amino Acid Sequence | 83-aa analog (Arg3 + N-terminal extension) | Aib-His-D-2-Nal-D-Phe-Lys-NH2 |
| CAS Number | 946870-92-4 | 170851-70-4 |
| Half-Life | ~20-30 h | ~2 hours |
| Studied For | Muscle growth / hypertrophy, Anabolic research, GH axis signaling, Lean mass increase | GH secretagogue research, Anti-aging / longevity via GH axis, Body composition improvement, Lean muscle gain |
About IGF-1 LR3
A potent long-acting IGF-1 analog used as a lab reagent; hypoglycemia and growth risks; banned in sport.
Read The Full IGF-1 LR3 MonographAbout Ipamorelin
A selective, clean growth-hormone-releasing peptide; banned in sport.
Read The Full Ipamorelin MonographKey Differences
- Reported half-life differs: IGF-1 LR3 at ~20-30 h versus Ipamorelin at ~2 hours.
- Primary molecular target differs: IGF-1 LR3 acts on IGF-1 receptor (IGF1R); PI3K/Akt/mTOR signaling; satellite cell proliferation; reduced IGFBP binding = extended half-life; Ipamorelin acts on GHS-R1a (ghrelin receptor) agonist; highly selective for pituitary GH release without significant ACTH/cortisol elevation.
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This Comparison Is Provided For In Vitro Laboratory Research Use Only. Not For Human Consumption, Diagnosis, Or Treatment. See The Full Research Disclaimer.