5-Amino-1MQ
Also Known As: 5-Amino-1-methylquinolinium, 5A1MQ, 5-amino-1-methylquinolinium salt, NNMT inhibitor 5-amino-1mq, Nicotinamide N-methyltransferase inhibitor, 5-amino 1MQ, Small molecule fat loss, NNMT blocker, 5AMQ, Metabolic NNMT inhibitor, 5-amino-1MQ salt, 1-methyl-5-aminoquinolinium, 5-amino-1-methylquinolinium, NNMT inhibitor, 5amino1mq
5-Amino-1MQ is a research-grade Small-molecule NNMT inhibitor targeting Nicotinamide N-methyltransferase studied in Weight Loss & Metabolism research. It is supplied strictly for in vitro laboratory research use only - not for human or animal consumption, and not FDA-approved.
Evidence Tier: Research Compound - No approved human use; sold for laboratory research only.
A small-molecule NNMT inhibitor studied in mice for fat loss; no human trials.
At A Glance
| Category | Weight Loss & Metabolism |
|---|---|
| Compound Class | Small-molecule NNMT inhibitor (quinolinium salt); not a peptide |
| Molecular Target | Nicotinamide N-methyltransferase (NNMT) inhibition; preserves SAM and NAD+ pools; reduces adipogenesis; enhances energy expenditure |
| Molecular Weight | 286.11 Da |
| Amino Acid Sequence | small molecule (quinolinium) |
| CAS Number | 42464-96-0 (5-amino-1-methylquinolinium iodide; also cited as 685079-15-6) |
| Half-Life | ~4 hours |
| WADA Status | not_listed |
| Evidence Tier | Research Compound |
Mechanism Of Action
It works by blocking a specific enzyme (NNMT) that normally slows down your cellular engines. By stopping this enzyme, your body starts using up more fuel and fat naturally.
Studied For
- Obesity / metabolic syndrome
- Fat-loss / energy-expenditure research
- NAD+ metabolism enhancement
- NNMT inhibition
- Adipogenesis inhibition
- Adipocyte differentiation blocking
- Lean mass preservation
- Insulin sensitivity improvement
- Lipid metabolism
- Diet-induced obesity models
- Weight management without appetite suppression
- SAM (S-adenosyl methionine) pool preservation
- Epigenetic metabolic regulation
- Mitochondrial efficiency
- Exercise performance
- fat burning
- metabolism booster
- weight loss
- muscle wasting prevention
- cellular energy
- anti-aging
- NAD+ salvage pathway
Reported Research Findings
Diet-induced-obese mice showed reduced body weight and fat mass without changed food intake. There are no completed published human trials; all claims are animal or in vitro. Preliminary.
Safety And Handling Notes
No adverse effects in short rodent studies; essentially no human safety data; chronic effects on the methylation pool are uncharacterized.
Strictly investigational with no human approval and no defined human dose. Identity resolved 2026-08-04: the research material is the iodide salt, CAS 42464-96-0, 286.11 Da (cation 159.21 Da); confirm the salt form on the supplier certificate of analysis because potency is quoted on different bases.
Regulatory Status
Not approved; research chemical.
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