MOTS-c vs 5-Amino-1MQ: Research Comparison
A Side-By-Side Research Comparison Of MOTS-c And 5-Amino-1MQ - two metabolic research compounds targeting mitochondrial and NNMT pathways. This Reference Compares Mechanism, Evidence Tier, Molecular Identity, And Pharmacokinetics For Qualified Researchers. For In Vitro Laboratory Research Use Only. Not Medical Advice Or Dosing Guidance.
Side-By-Side Comparison
| MOTS-c | 5-Amino-1MQ | |
|---|---|---|
| Category | Weight Loss & Metabolism | Weight Loss & Metabolism |
| Compound Class | Mitochondrial-derived peptide (MDP) encoded within 12S rRNA of mitochondrial genome | Small-molecule NNMT inhibitor (quinolinium salt); not a peptide |
| Evidence Tier | Research Compound | Research Compound |
| Molecular Target | AMPK activation; folate-methionine cycle; AICAR-independent AMPK signaling; nuclear translocation for gene expression regulation | Nicotinamide N-methyltransferase (NNMT) inhibition; preserves SAM and NAD+ pools; reduces adipogenesis; enhances energy expenditure |
| Molecular Weight | 2174.6 Da | 286.11 Da |
| Amino Acid Sequence | MRWQEMGYIFYPRKLR | small molecule (quinolinium) |
| CAS Number | 1627580-64-6 | 42464-96-0 (5-amino-1-methylquinolinium iodide; also cited as 685079-15-6) |
| Half-Life | ~30 minutes | ~4 hours |
| Studied For | Metabolic homeostasis, Insulin resistance / obesity, Exercise-mimetic research, AMPK activation | Obesity / metabolic syndrome, Fat-loss / energy-expenditure research, NAD+ metabolism enhancement, NNMT inhibition |
About MOTS-c
A mitochondrial exercise-mimetic peptide; banned in sport since 2024, mostly preclinical.
Read The Full MOTS-c MonographAbout 5-Amino-1MQ
A small-molecule NNMT inhibitor studied in mice for fat loss; no human trials.
Read The Full 5-Amino-1MQ MonographKey Differences
- Reported half-life differs: MOTS-c at ~30 minutes versus 5-Amino-1MQ at ~4 hours.
- Primary molecular target differs: MOTS-c acts on AMPK activation; folate-methionine cycle; AICAR-independent AMPK signaling; nuclear translocation for gene expression regulation; 5-Amino-1MQ acts on Nicotinamide N-methyltransferase (NNMT) inhibition; preserves SAM and NAD+ pools; reduces adipogenesis; enhances energy expenditure.
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This Comparison Is Provided For In Vitro Laboratory Research Use Only. Not For Human Consumption, Diagnosis, Or Treatment. See The Full Research Disclaimer.