NAD+
Also Known As: Nicotinamide adenine dinucleotide, NAD, NAD+ coenzyme, NAD plus, Beta-nicotinamide adenine dinucleotide, NAD IV therapy, NAD infusion, Oxidized NAD, Coenzyme I, DPN (diphosphopyridine nucleotide), NAD supplement, NADH precursor, Cellular energy coenzyme, Sirtuin activator cofactor, Anti-aging NAD, Nicotinamide Adenine Dinucleotide, NAD+, anti-aging
NAD+ is a research-grade Essential coenzyme targeting Sirtuin deacetylases studied in Anti-Aging & Longevity research. It is supplied strictly for in vitro laboratory research use only - not for human or animal consumption, and not FDA-approved.
Evidence Tier: Research Compound - No approved human use; sold for laboratory research only.
A metabolic coenzyme given by injection or IV in wellness settings; rigorous human evidence mostly involves oral precursors.
At A Glance
| Category | Anti-Aging & Longevity |
|---|---|
| Compound Class | Essential coenzyme (dinucleotide); critical redox electron carrier in all living cells |
| Molecular Target | Sirtuin deacetylases (SIRT1-7); PARP1 for DNA repair; CD38/CD157 signaling; NADH/NAD+ redox balance in mitochondria |
| Molecular Weight | 663.43 Da |
| Amino Acid Sequence | dinucleotide |
| CAS Number | 53-84-9 |
| Half-Life | ~2-4 hours |
| WADA Status | not_listed |
| Evidence Tier | Research Compound |
Mechanism Of Action
It acts as the critical coenzyme in the mitochondria required to produce ATP (cellular energy). Restoring NAD+ levels directly increases cellular energy output and activates anti-aging repair genes (sirtuins).
Studied For
- Aging / cellular senescence
- Mitochondrial / metabolic dysfunction
- Neurodegeneration models
- Sirtuin activation (SIRT1-7)
- DNA repair (PARP activation)
- Addiction / substance withdrawal research
- Chronic fatigue / energy restoration
- Alzheimer's and Parkinson's research
- Alcohol use disorder detox
- Metabolic syndrome
- Insulin resistance
- Cardiovascular disease models
- Exercise performance and endurance
- Inflammation modulation
- NAD metabolism optimization
- Longevity research
- NAMPT upregulation
- Cognitive enhancement
- Depression research
- energy production
- anti-aging
- longevity
- mitochondrial function
- sirtuin activator
- addiction recovery
- brain fog
Reported Research Findings
Animal and precursor human studies support raising NAD+ for mitochondrial and sirtuin function. Direct injectable NAD+ human efficacy is sparse and uncontrolled; preliminary.
Safety And Handling Notes
Rapid IV infusion commonly causes chest tightness, flushing, nausea, and cramping that are rate-dependent and eased by slow infusion. Injection-site reactions for subcutaneous use.
Compounded injectable; not FDA-approved; parenteral pharmacokinetics are poorly characterized.
Regulatory Status
Not FDA-approved (compounded injectable); oral precursors sold as supplements.
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This Reference Is Provided For In Vitro Laboratory Research Use Only. Not For Human Consumption. See The Full Research Disclaimer.