SS-31 vs NAD+: Research Comparison
A Side-By-Side Research Comparison Of SS-31 And NAD+ - a mitochondrial-targeted peptide versus NAD+ in cellular-energy research. This Reference Compares Mechanism, Evidence Tier, Molecular Identity, And Pharmacokinetics For Qualified Researchers. For In Vitro Laboratory Research Use Only. Not Medical Advice Or Dosing Guidance.
Side-By-Side Comparison
| SS-31 | NAD+ | |
|---|---|---|
| Category | Anti-Aging & Longevity | Anti-Aging & Longevity |
| Compound Class | Mitochondria-targeted tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2); cardiolipin-targeting | Essential coenzyme (dinucleotide); critical redox electron carrier in all living cells |
| Evidence Tier | Approved Drug | Research Compound |
| Molecular Target | Cardiolipin on inner mitochondrial membrane; scavenges mitochondrial ROS; stabilizes cristae architecture; restores respiratory chain efficiency | Sirtuin deacetylases (SIRT1-7); PARP1 for DNA repair; CD38/CD157 signaling; NADH/NAD+ redox balance in mitochondria |
| Molecular Weight | 639.79 Da | 663.43 Da |
| Amino Acid Sequence | D-Arg-Dmt-Lys-Phe-NH2 | dinucleotide |
| CAS Number | 736992-21-5 | 53-84-9 |
| Half-Life | ~4 hours | ~2-4 hours |
| Studied For | Primary mitochondrial disease, Barth syndrome (cardiolipin deficiency), Heart failure / ischemia-reperfusion injury, Dry AMD (age-related macular degeneration) | Aging / cellular senescence, Mitochondrial / metabolic dysfunction, Neurodegeneration models, Sirtuin activation (SIRT1-7) |
About SS-31
A mitochondria-protecting peptide newly approved for the rare Barth syndrome and studied broadly for mitochondrial and heart conditions.
Read The Full SS-31 MonographAbout NAD+
A metabolic coenzyme given by injection or IV in wellness settings; rigorous human evidence mostly involves oral precursors.
Read The Full NAD+ MonographKey Differences
- Evidence tier differs: SS-31 is classified as Approved Drug; NAD+ is classified as Research Compound.
- Reported half-life differs: SS-31 at ~4 hours versus NAD+ at ~2-4 hours.
- Primary molecular target differs: SS-31 acts on Cardiolipin on inner mitochondrial membrane; scavenges mitochondrial ROS; stabilizes cristae architecture; restores respiratory chain efficiency; NAD+ acts on Sirtuin deacetylases (SIRT1-7); PARP1 for DNA repair; CD38/CD157 signaling; NADH/NAD+ redox balance in mitochondria.
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This Comparison Is Provided For In Vitro Laboratory Research Use Only. Not For Human Consumption, Diagnosis, Or Treatment. See The Full Research Disclaimer.