SS-31 vs NAD+: Research Comparison

A Side-By-Side Research Comparison Of SS-31 And NAD+ - a mitochondrial-targeted peptide versus NAD+ in cellular-energy research. This Reference Compares Mechanism, Evidence Tier, Molecular Identity, And Pharmacokinetics For Qualified Researchers. For In Vitro Laboratory Research Use Only. Not Medical Advice Or Dosing Guidance.

Side-By-Side Comparison

SS-31 versus NAD+ research comparison
	SS-31	NAD+
Category	Anti-Aging & Longevity	Anti-Aging & Longevity
Compound Class	Mitochondria-targeted tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2); cardiolipin-targeting	Essential coenzyme (dinucleotide); critical redox electron carrier in all living cells
Evidence Tier	Approved Drug	Research Compound
Molecular Target	Cardiolipin on inner mitochondrial membrane; scavenges mitochondrial ROS; stabilizes cristae architecture; restores respiratory chain efficiency	Sirtuin deacetylases (SIRT1-7); PARP1 for DNA repair; CD38/CD157 signaling; NADH/NAD+ redox balance in mitochondria
Molecular Weight	639.79 Da	663.43 Da
Amino Acid Sequence	D-Arg-Dmt-Lys-Phe-NH2	dinucleotide
CAS Number	736992-21-5	53-84-9
Half-Life	~4 hours	~2-4 hours
Studied For	Primary mitochondrial disease, Barth syndrome (cardiolipin deficiency), Heart failure / ischemia-reperfusion injury, Dry AMD (age-related macular degeneration)	Aging / cellular senescence, Mitochondrial / metabolic dysfunction, Neurodegeneration models, Sirtuin activation (SIRT1-7)

Open SS-31 And NAD+ In The Interactive Comparison Tool

About SS-31

A mitochondria-protecting peptide newly approved for the rare Barth syndrome and studied broadly for mitochondrial and heart conditions.

Read The Full SS-31 Monograph

About NAD+

A metabolic coenzyme given by injection or IV in wellness settings; rigorous human evidence mostly involves oral precursors.

Read The Full NAD+ Monograph

Key Differences

Evidence tier differs: SS-31 is classified as Approved Drug; NAD+ is classified as Research Compound.
Reported half-life differs: SS-31 at ~4 hours versus NAD+ at ~2-4 hours.
Primary molecular target differs: SS-31 acts on Cardiolipin on inner mitochondrial membrane; scavenges mitochondrial ROS; stabilizes cristae architecture; restores respiratory chain efficiency; NAD+ acts on Sirtuin deacetylases (SIRT1-7); PARP1 for DNA repair; CD38/CD157 signaling; NADH/NAD+ redox balance in mitochondria.

Continue Researching

SS-31 · NAD+ · Compare Tool · Research Library

This Comparison Is Provided For In Vitro Laboratory Research Use Only. Not For Human Consumption, Diagnosis, Or Treatment. See The Full Research Disclaimer.