Vitamin B12

Also Known As: Methylcobalamin, Cyanocobalamin, Cobalamin, Hydroxocobalamin, Adenosylcobalamin, B12, Vitamin B-12, Mecobalamin, MeCbl, CNCbl, Cobamamide, Methylcobalamin injection, B12 shot, B12 injection, Cobalamin B12, Neurological vitamin B12, Energy vitamin B12, cobalamin

Vitamin B12 is a research-grade Water-soluble vitamin B12 targeting Methionine synthase studied in Immunity & Wellness research. It is supplied strictly for in vitro laboratory research use only - not for human or animal consumption, and not FDA-approved.

Evidence Tier: Approved Drug - FDA and/or EMA approved with robust human trial data.

Injectable vitamin B12, used to correct deficiency; an approved drug.

At A Glance

Vitamin B12 Key Research Facts
CategoryImmunity & Wellness
Compound ClassWater-soluble vitamin B12 (cobalamin); essential coenzyme for methylation and myelin synthesis
Molecular TargetMethionine synthase (methylcobalamin form); methylmalonyl-CoA mutase (adenosylcobalamin form); DNA synthesis; myelin basic protein maintenance
Molecular Weight1355.37 Da
Amino Acid Sequencecorrinoid
CAS Number68-19-9 (cyano); 13422-55-4 (methyl)
Half-Life~6 days
WADA Statusnot_listed
Evidence TierApproved Drug

Mechanism Of Action

It provides a missing piece that your cells need to copy DNA and create red blood cells. Without it, the body's energy factory stalls out.

Studied For

  • Vitamin B12 deficiency / pernicious anemia
  • Megaloblastic anemia
  • Peripheral neuropathy support
  • Neurological disease (subacute combined degeneration)
  • Cognitive decline / dementia prevention
  • Homocysteine reduction
  • Cardiovascular risk via homocysteine
  • Fatigue and energy restoration
  • Methylation pathway support
  • Immune function support
  • Pregnancy (neural tube prevention)
  • Vegan/vegetarian supplementation
  • Methyl donor coenzyme
  • DNA synthesis support
  • Myelin sheath maintenance
  • energy boost
  • nerve health
  • metabolism
  • red blood cell production
  • fatigue
  • neuropathy

Reported Research Findings

Established human use: corrects deficiency anemia and many neurologic deficits. Energy-boost claims in non-deficient people are not supported.

Safety And Handling Notes

Very safe; injection-site pain, mild diarrhea, rare hypersensitivity.

Avoid cyanocobalamin in Leber optic neuropathy and tobacco amblyopia; cobalt hypersensitivity is a contraindication.

Regulatory Status

FDA-approved prescription/OTC drug; also a supplement.

Full Reference Detail

Related Research Guides

Maintained By The Pep Nation Lab Research Team. See Our Editorial Standards And Research Methodology For How This Reference Is Sourced And Reviewed.

This Reference Is Provided For In Vitro Laboratory Research Use Only. Not For Human Consumption. See The Full Research Disclaimer.

References And Citations

  1. PubMed / NCBI Reference
  2. ClinicalTrials.gov Record
Spec Sheet

Vitamin B12

Also Known As: Methylcobalamin, Cyanocobalamin, Cobalamin, Hydroxocobalamin, Adenosylcobalamin, B12, Vitamin B-12, Mecobalamin, MeCbl, CNCbl, Cobamamide, Methylcobalamin injection, B12 shot, B12 injection, Cobalamin B12, Neurological vitamin B12, Energy vitamin B12, cobalamin

Approved DrugImmunity & Wellness

Explain Like I'm 5

  • Vitamin B12 is like the spark plug for your body's energy engine. It helps build healthy red blood cells, keeps your nerves firing fast, and turns the food you eat into pure, usable energy.

Injectable vitamin B12, used to correct deficiency; an approved drug.

Identity & Classification
Vitamin B12 Key Research Facts
ClassWater-soluble vitamin B12 (cobalamin); essential coenzyme for methylation and myelin synthesis
Molecular TargetMethionine synthase (methylcobalamin form); methylmalonyl-CoA mutase (adenosylcobalamin form); DNA synthesis; myelin basic protein maintenance
CategoryImmunity & Wellness
Molecular Weight1355.37 Da
Amino Acid Sequencecorrinoid
CAS Number68-19-9 (cyano); 13422-55-4 (methyl)
Parent CompoundCobalamin
Research Metrics at a Glance
28,593
PubMed Citations
589
Clinical Trials
589 Active

Related Compounds

Research Use Only. Not For Human Or Veterinary Use. Information Provided For Laboratory Research Purposes Only.

Research Reference Only — Not Medical Advice. For In Vitro Laboratory Use Only.
Typical Dose500–1000 mcg (cyanocobalamin or methylcobalamin)
FrequencyOnce daily (deficiency research); once weekly (maintenance)
Cycle OnOngoing (repleted as needed based on serum levels)
Cycle OffN/A — essential nutrient supplementation
Route(s)
SubcutaneousIntramuscularSublingual (oral research)
Research Notes

IM injection provides highest bioavailability (bypasses intrinsic factor). Subcutaneous comparable to IM for cobalamin. Methylcobalamin preferred for neurological research. Cyanocobalamin lowest cost; hydroxocobalamin longest retention. Serum B12 monitoring recommended in research protocols.

Sequence Motif Viewer

9 Residues
CORRINOID
BasicAcidicPolarNon-PolarAromaticSpecial
CompoundCompoundTargetReceptor / TargetIt provides a missin...Downstream PathwayResearch EffectStudied Effect

Vitamin B12 Frequently Asked Questions

What Is Vitamin B12?

Injectable vitamin B12, used to correct deficiency; an approved drug.

How Does Vitamin B12 Work?

It provides a missing piece that your cells need to copy DNA and create red blood cells. Without it, the body's energy factory stalls out.

What Has Vitamin B12 Been Studied For?

In the referenced literature, Vitamin B12 has been studied for Vitamin B12 deficiency / pernicious anemia, Megaloblastic anemia, Peripheral neuropathy support, Neurological disease (subacute combined degeneration), Cognitive decline / dementia prevention, Homocysteine reduction, Cardiovascular risk via homocysteine, Fatigue and energy restoration, Methylation pathway support, Immune function support, Pregnancy (neural tube prevention), Vegan/vegetarian supplementation, Methyl donor coenzyme, DNA synthesis support, Myelin sheath maintenance, energy boost, nerve health, metabolism, red blood cell production, fatigue, neuropathy. This summarizes research focus only and is not a claim of efficacy.

What Is The Reported Half-Life Of Vitamin B12?

Vitamin B12 has a reported half-life of ~6 days in the referenced literature.

Is Vitamin B12 Approved For Human Use?

No. Vitamin B12 is supplied strictly for in vitro laboratory research use only. It is not intended for human or animal consumption, ingestion, or injection, and it has not been evaluated by the FDA.

Regional Research Availability

Pep Nation Lab supplies research-grade Vitamin B12 to qualified researchers and scientific institutions nationwide. Browse verified availability and per-region documentation by state:

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