Epithalon vs NAD+: Research Comparison
A Side-By-Side Research Comparison Of Epithalon And NAD+ - a telomerase-pathway peptide versus NAD+ metabolism in longevity research. This Reference Compares Mechanism, Evidence Tier, Molecular Identity, And Pharmacokinetics For Qualified Researchers. For In Vitro Laboratory Research Use Only. Not Medical Advice Or Dosing Guidance.
Side-By-Side Comparison
| Epithalon | NAD+ | |
|---|---|---|
| Category | Anti-Aging & Longevity | Anti-Aging & Longevity |
| Compound Class | Synthetic tetrapeptide bioregulator derived from pineal gland epithalamin | Essential coenzyme (dinucleotide); critical redox electron carrier in all living cells |
| Evidence Tier | Research Compound | Research Compound |
| Molecular Target | Telomerase activation (TERT); pineal melatonin synthesis; antioxidant enzyme upregulation | Sirtuin deacetylases (SIRT1-7); PARP1 for DNA repair; CD38/CD157 signaling; NADH/NAD+ redox balance in mitochondria |
| Molecular Weight | 390.35 Da | 663.43 Da |
| Amino Acid Sequence | Ala-Glu-Asp-Gly (AEDG) | dinucleotide |
| CAS Number | 307297-39-8 | 53-84-9 |
| Half-Life | ~10-15 minutes | ~2-4 hours |
| Studied For | Telomere elongation, Anti-aging / longevity, Circadian rhythm regulation, Antioxidant defense | Aging / cellular senescence, Mitochondrial / metabolic dysfunction, Neurodegeneration models, Sirtuin activation (SIRT1-7) |
About Epithalon
A short pineal-derived peptide studied for telomere and aging biology. Evidence is mostly cell-culture and animal; human data are preliminary.
Read The Full Epithalon MonographAbout NAD+
A metabolic coenzyme given by injection or IV in wellness settings; rigorous human evidence mostly involves oral precursors.
Read The Full NAD+ MonographKey Differences
- Reported half-life differs: Epithalon at ~10-15 minutes versus NAD+ at ~2-4 hours.
- Primary molecular target differs: Epithalon acts on Telomerase activation (TERT); pineal melatonin synthesis; antioxidant enzyme upregulation; NAD+ acts on Sirtuin deacetylases (SIRT1-7); PARP1 for DNA repair; CD38/CD157 signaling; NADH/NAD+ redox balance in mitochondria.
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This Comparison Is Provided For In Vitro Laboratory Research Use Only. Not For Human Consumption, Diagnosis, Or Treatment. See The Full Research Disclaimer.