FOXO4-DRI vs Epithalon: Research Comparison
A Side-By-Side Research Comparison Of FOXO4-DRI And Epithalon - a senolytic peptide versus a telomerase-pathway peptide in longevity research. This Reference Compares Mechanism, Evidence Tier, Molecular Identity, And Pharmacokinetics For Qualified Researchers. For In Vitro Laboratory Research Use Only. Not Medical Advice Or Dosing Guidance.
Side-By-Side Comparison
| FOXO4-DRI | Epithalon | |
|---|---|---|
| Category | Anti-Aging & Longevity | Anti-Aging & Longevity |
| Compound Class | D-retro-inverso peptide; protease-resistant cell-penetrating senolytic | Synthetic tetrapeptide bioregulator derived from pineal gland epithalamin |
| Evidence Tier | Preclinical | Research Compound |
| Molecular Target | FOXO4-p53 protein-protein interaction; disrupts pro-survival signaling in senescent cells, inducing selective apoptosis | Telomerase activation (TERT); pineal melatonin synthesis; antioxidant enzyme upregulation |
| Molecular Weight | 5223 Da | 390.35 Da |
| Amino Acid Sequence | ~43-residue D-amino-acid retro-inverso FOXO4 analog | Ala-Glu-Asp-Gly (AEDG) |
| CAS Number | not standardized | 307297-39-8 |
| Half-Life | ~24-36 hours | ~10-15 minutes |
| Studied For | Senolytics / senescent cell clearance, Aging / healthspan extension, Chemotherapy-induced senescence reversal, Physical fitness restoration in aging models | Telomere elongation, Anti-aging / longevity, Circadian rhythm regulation, Antioxidant defense |
About FOXO4-DRI
An experimental senolytic peptide that clears aged (senescent) cells in mice. No human data; strictly preclinical.
Read The Full FOXO4-DRI MonographAbout Epithalon
A short pineal-derived peptide studied for telomere and aging biology. Evidence is mostly cell-culture and animal; human data are preliminary.
Read The Full Epithalon MonographKey Differences
- Evidence tier differs: FOXO4-DRI is classified as Preclinical; Epithalon is classified as Research Compound.
- Reported half-life differs: FOXO4-DRI at ~24-36 hours versus Epithalon at ~10-15 minutes.
- Primary molecular target differs: FOXO4-DRI acts on FOXO4-p53 protein-protein interaction; disrupts pro-survival signaling in senescent cells, inducing selective apoptosis; Epithalon acts on Telomerase activation (TERT); pineal melatonin synthesis; antioxidant enzyme upregulation.
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This Comparison Is Provided For In Vitro Laboratory Research Use Only. Not For Human Consumption, Diagnosis, Or Treatment. See The Full Research Disclaimer.