SNAP-8
Also Known As: Acetyl Octapeptide-3, SNAP 8, Acetyl Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2, Argireline analog 8-peptide, SNAP-8 octapeptide, Acetyl octapeptide, Expression line peptide, Anti-wrinkle octapeptide, Botox-like peptide topical, Syn-Ake competitor peptide, Snap8 cosmetic peptide, anti-wrinkle, argireline analog, acetyl octapeptide-3
SNAP-8 is a research-grade Synthetic acetylated octapeptide targeting SNAP-25 studied in Skin, Hair & Cosmetics research. It is supplied strictly for in vitro laboratory research use only - not for human or animal consumption, and not FDA-approved.
Evidence Tier: Cosmetic - Recognized topical cosmetic active, not a drug.
A topical anti-wrinkle peptide; cosmetic use only.
At A Glance
| Category | Skin, Hair & Cosmetics |
|---|---|
| Compound Class | Synthetic acetylated octapeptide; SNAP-25 mimetic for topical anti-wrinkle use |
| Molecular Target | SNAP-25 (synaptosomal-associated protein 25); competes for SNARE complex assembly; reduces acetylcholine vesicle fusion at neuromuscular junction |
| Molecular Weight | 1075.2 Da |
| Amino Acid Sequence | Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 |
| CAS Number | 868844-74-0 |
| Half-Life | ~1-2 hours |
| WADA Status | not_listed |
| Evidence Tier | Cosmetic |
Mechanism Of Action
It slightly interrupts the chemical signal that tells facial muscles to contract. By reducing the intensity of the muscle contraction, the skin above it stops folding, reducing the depth of wrinkles.
Studied For
- Topical anti-wrinkle / expression lines
- SNAP-25 mimicry to reduce muscle contraction
- Forehead wrinkle reduction
- Crow's feet reduction
- Glabellar line reduction
- Botulinum toxin analog topical
- Expression line depth reduction
- SNARE complex disruption topical
- Acetylcholine vesicle release inhibition
- Facial anti-aging cosmetic research
- Neuromuscular junction modulation topical
- Dynamic wrinkle prevention
- skin smoothing
- cosmetic
- expression lines
- wrinkle reduction
Reported Research Findings
Manufacturer and cosmetic studies report wrinkle-depth reduction with topical use; evidence is largely industry-sponsored on small cohorts.
Safety And Handling Notes
Low-risk topically; possible mild local irritation; limited skin penetration both reduces risk and limits efficacy.
A topical cosmetic ingredient, not an injectable or drug; modest efficacy; not a botulinum substitute.
Regulatory Status
Cosmetic ingredient (INCI: Acetyl Octapeptide-3); not a drug.
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This Reference Is Provided For In Vitro Laboratory Research Use Only. Not For Human Consumption. See The Full Research Disclaimer.