Technical Data Sheet
SNAP-8
Also Known As: Acetyl Octapeptide-3, SNAP 8, Acetyl Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2, Argireline analog 8-peptide, SNAP-8 octapeptide, Acetyl octapeptide, Expression line peptide, Anti-wrinkle octapeptide, Botox-like peptide topical, Syn-Ake competitor peptide, Snap8 cosmetic peptide, anti-wrinkle, argireline analog, acetyl octapeptide-3
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| Evidence Tier | Cosmetic |
|---|---|
| Category | Skin, Hair & Cosmetics |
| Class | Synthetic acetylated octapeptide; SNAP-25 mimetic for topical anti-wrinkle use |
| Molecular Target | SNAP-25 (synaptosomal-associated protein 25); competes for SNARE complex assembly; reduces acetylcholine vesicle fusion at neuromuscular junction |
| Sequence | Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 |
| Molecular Weight | ~1075 g/mol |
| CAS | 868844-74-0 |
| Parent | SNAP-25 mimic (Argireline extension) |
| Mechanism | It slightly interrupts the chemical signal that tells facial muscles to contract. By reducing the intensity of the muscle contraction, the skin above it stops folding, reducing the depth of wrinkles. |
| Studied For | Topical anti-wrinkle / expression lines, SNAP-25 mimicry to reduce muscle contraction, Forehead wrinkle reduction, Crow's feet reduction, Glabellar line reduction, Botulinum toxin analog topical, Expression line depth reduction, SNARE complex disruption topical, Acetylcholine vesicle release inhibition, Facial anti-aging cosmetic research, Neuromuscular junction modulation topical, Dynamic wrinkle prevention, skin smoothing, cosmetic, expression lines, wrinkle reduction |
| Administration Route | Injection Only |
| Form | aqueous concentrate or powder |
| Diluent | water (formulation) |
| Storage Temperature | cool, dark |
| Light Sensitive | Yes |
| Freeze / Thaw | avoid |
| Reconstituted Shelf Life | 30 Days |
| Handling Notes | Methionine residue is oxidation-sensitive. |
| Regulatory | Cosmetic ingredient (INCI: Acetyl Octapeptide-3); not a drug. |
| Sources |