BPC-157 vs TB-500 / Thymosin Beta-4: Research Comparison
A Side-By-Side Research Comparison Of BPC-157 And TB-500 / Thymosin Beta-4 - the two most-studied research peptides for tissue repair and recovery. This Reference Compares Mechanism, Evidence Tier, Molecular Identity, And Pharmacokinetics For Qualified Researchers. For In Vitro Laboratory Research Use Only. Not Medical Advice Or Dosing Guidance.
Side-By-Side Comparison
| BPC-157 | TB-500 / Thymosin Beta-4 | |
|---|---|---|
| Category | Healing & Recovery | Healing & Recovery |
| Compound Class | Synthetic pentadecapeptide derived from human gastric juice protein BPC | Endogenous 43-amino acid thymic peptide; G-actin sequestrant and tissue-protection factor |
| Evidence Tier | Research Compound | Research Compound |
| Molecular Target | NO-synthase, VEGF, FAK/paxillin, EGF receptor, growth hormone receptor; promotes angiogenesis, collagen synthesis, and cytoprotection | G-actin sequestration (Wiskott-Aldrich Syndrome protein WH2 domain); VEGF upregulation; integrin-linked kinase (ILK); thymosin beta-4 receptor (Tβ4R) |
| Molecular Weight | 1419.5 Da | 4963.4 Da |
| Amino Acid Sequence | Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val | full Tbeta4 43 aa; TB-500 marketed fragment Ac-LKKTETQ |
| CAS Number | 137525-51-0 | 77591-33-4 (Tbeta4) |
| Half-Life | ~30 minutes | ~30 hours |
| Studied For | GI mucosal healing, Tendon / ligament repair, Nerve repair, Anti-inflammatory | Dermal / corneal wound healing, Cardiac repair models, Tendon / ligament / muscle injury, Hair growth stimulation |
About BPC-157
A popular research healing peptide with strong rodent data but very limited human evidence.
Read The Full BPC-157 MonographAbout TB-500 / Thymosin Beta-4
A research repair peptide that regulates the cytoskeleton; banned in sport and often mislabeled.
Read The Full TB-500 / Thymosin Beta-4 MonographKey Differences
- Reported half-life differs: BPC-157 at ~30 minutes versus TB-500 / Thymosin Beta-4 at ~30 hours.
- Primary molecular target differs: BPC-157 acts on NO-synthase, VEGF, FAK/paxillin, EGF receptor, growth hormone receptor; promotes angiogenesis, collagen synthesis, and cytoprotection; TB-500 / Thymosin Beta-4 acts on G-actin sequestration (Wiskott-Aldrich Syndrome protein WH2 domain); VEGF upregulation; integrin-linked kinase (ILK); thymosin beta-4 receptor (Tβ4R).
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BPC-157 · TB-500 / Thymosin Beta-4 · Compare Tool · Research Library
This Comparison Is Provided For In Vitro Laboratory Research Use Only. Not For Human Consumption, Diagnosis, Or Treatment. See The Full Research Disclaimer.