GHRP-6
Also Known As: GHRP6, Growth Hormone Releasing Hexapeptide, GHRP-6 peptide, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2, GH-releasing hexapeptide, Growth hormone secretagogue hexapeptide, GH releasing peptide 6, GHRP 6, Hexarelin precursor, Hunger peptide, hunger peptide
GHRP-6 is a research-grade Synthetic hexapeptide GH secretagogue targeting GHS-R1a studied in Muscle Growth & Performance research. It is supplied strictly for in vitro laboratory research use only - not for human or animal consumption, and not FDA-approved.
Evidence Tier: Research Compound - No approved human use; sold for laboratory research only.
The original growth-hormone-releasing peptide; strong appetite effect; banned in sport.
At A Glance
| Category | Muscle Growth & Performance |
|---|---|
| Compound Class | Synthetic hexapeptide GH secretagogue (GHRP); first-generation ghrelin mimetic |
| Molecular Target | GHS-R1a (ghrelin receptor) agonist; stimulates pituitary GH release and endogenous ghrelin; strong appetite/hunger signal |
| Molecular Weight | 873.01 Da |
| Amino Acid Sequence | His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 |
| CAS Number | 87616-84-0 |
| Half-Life | ~2.5 hours |
| WADA Status | prohibited |
| Evidence Tier | Research Compound |
Mechanism Of Action
It is a strong activator of the ghrelin receptor. While it causes a pulse of growth hormone, it also sends an overpowering signal to the stomach and brain to increase appetite immediately.
Studied For
- GH release stimulation
- Appetite stimulation / hunger research
- GI motility research
- GH secretagogue research
- IGF-1 elevation
- Muscle growth via GH axis
- Fat loss via GH
- Body composition research
- Ghrelin axis signaling
- Pituitary GH function testing
- Anti-aging via GH
- Gastric motility and emptying
- Cytoprotective GI effects
- GH pulse amplitude research
- Lean mass increase
- appetite stimulation
- growth hormone secretagogue
- gastric motility
- muscle growth
- recovery
Reported Research Findings
Human studies show dose-dependent growth-hormone release and GHRH synergy; animal data suggest cardioprotection. Mostly mechanistic; no approved indication.
Safety And Handling Notes
Pronounced appetite increase; dose-dependent cortisol and prolactin elevation; flushing, fatigue, water retention.
Not approved; growth-hormone-axis risks apply. WADA-prohibited. Research use only.
Regulatory Status
Not FDA-approved; research chemical; WADA S2.
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