Selank vs Semax: Research Comparison
A Side-By-Side Research Comparison Of Selank And Semax - two Russian-developed nootropic and anxiolytic research peptides. This Reference Compares Mechanism, Evidence Tier, Molecular Identity, And Pharmacokinetics For Qualified Researchers. For In Vitro Laboratory Research Use Only. Not Medical Advice Or Dosing Guidance.
Side-By-Side Comparison
| Selank | Semax | |
|---|---|---|
| Category | Immunity & Wellness | Immunity & Wellness |
| Compound Class | Synthetic heptapeptide anxiolytic / nootropic; tuftsin analog (Thr-Lys-Pro-Arg-Pro-Gly-Pro) | Synthetic heptapeptide analog of ACTH 4-7 with Pro-Gly-Pro extension; neuroprotective and nootropic |
| Evidence Tier | Research Compound | Research Compound |
| Molecular Target | Enkephalinase inhibition; GABA-A receptor modulation; BDNF upregulation; serotonin/dopamine pathway; T-cell tuftsin receptor | Melanocortin receptors (MC2R/MC4R); BDNF/NGF upregulation; serotonin/dopamine axis; enkephalinase inhibition |
| Molecular Weight | 751.88 Da | 813.9 Da |
| Amino Acid Sequence | Thr-Lys-Pro-Arg-Pro-Gly-Pro | Met-Glu-His-Phe-Pro-Gly-Pro |
| CAS Number | 129954-34-3 | 80714-61-0 |
| Half-Life | ~2 minutes | ~5 minutes |
| Studied For | Generalized anxiety disorder research, Stress modulation, Cognition / attention / focus, Memory enhancement | Ischemic stroke recovery, Cognition / memory enhancement, Optic nerve disorders, CNS disorders research |
About Selank
A calming, nootropic peptide used in Russia for anxiety; Western evidence is thin.
Read The Full Selank MonographAbout Semax
A nootropic/neuroprotective peptide used in Russia for stroke and cognition.
Read The Full Semax MonographKey Differences
- Reported half-life differs: Selank at ~2 minutes versus Semax at ~5 minutes.
- Primary molecular target differs: Selank acts on Enkephalinase inhibition; GABA-A receptor modulation; BDNF upregulation; serotonin/dopamine pathway; T-cell tuftsin receptor; Semax acts on Melanocortin receptors (MC2R/MC4R); BDNF/NGF upregulation; serotonin/dopamine axis; enkephalinase inhibition.
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This Comparison Is Provided For In Vitro Laboratory Research Use Only. Not For Human Consumption, Diagnosis, Or Treatment. See The Full Research Disclaimer.