HGH Fragment 176-191
Also Known As: HGH Frag, AOD Fragment, Frag 176-191, HGH Fragment, Fragment 176-191, HGH 176-191, Growth hormone fragment 176-191, GH fragment 176-191, Lipolytic GH fragment, Fat-loss fragment, Frag176-191, C-terminal HGH fragment 176-191, Anti-obesity GH fragment
HGH Fragment 176-191 is a research-grade Synthetic fragment of HGH C-terminus targeting Beta-3 adrenergic receptors studied in Muscle Growth & Performance research. It is supplied strictly for in vitro laboratory research use only - not for human or animal consumption, and not FDA-approved.
Evidence Tier: Research Compound - No approved human use; sold for laboratory research only.
A growth-hormone fragment marketed for fat loss; human efficacy is unproven and it is banned in sport.
At A Glance
| Category | Muscle Growth & Performance |
|---|---|
| Compound Class | Synthetic fragment of HGH C-terminus (residues 176-191) |
| Molecular Target | Beta-3 adrenergic receptors; stimulates lipolysis without GH receptor binding; no IGF-1 elevation |
| Molecular Weight | 1817.1 Da |
| Amino Acid Sequence | 16-aa C-terminal lipolytic fragment of human growth hormone (residues 176-191) |
| CAS Number | 66004-57-7 |
| Half-Life | ~3 minutes |
| WADA Status | prohibited |
| Evidence Tier | Research Compound |
Mechanism Of Action
It isolates the specific sequence of amino acids responsible for fat breakdown (lipolysis). It attaches to fat cells and forces them to release stored fat without activating the IGF-1 growth pathways.
Studied For
- Lipolysis / fat loss
- Adipose reduction
- Visceral fat reduction
- Body composition improvement
- Subcutaneous fat burning
- Fat oxidation
- Anti-obesity research
- Weight management
- Metabolic rate enhancement
- Fat-loss peptide research
- Abdominal fat research
- Beta-3 adrenergic lipolysis
- Lean mass preservation during fat loss
- GH-fragment weight research
Reported Research Findings
Obese-mouse studies show reduced weight and increased fat oxidation. Human evidence for the fragment is minimal; most human data come from the related AOD9604, which was ultimately not significant.
Safety And Handling Notes
Limited formal human safety data; mainly injection-site reactions in unregulated use; long-term safety uncharacterized.
Not approved; human efficacy unproven; grey-market identity and purity are a major limitation. WADA-banned. Research use only.
Regulatory Status
Not FDA-approved; research chemical. Named on the WADA 2026 Prohibited List under S2.2.3 (growth hormone fragments); prohibited at all times and a non-Specified substance.
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This Reference Is Provided For In Vitro Laboratory Research Use Only. Not For Human Consumption. See The Full Research Disclaimer.