MOTS-c vs AOD9604: Research Comparison
A Side-By-Side Research Comparison Of MOTS-c And AOD9604 - a mitochondrial-derived peptide versus an HGH fragment in metabolic research. This Reference Compares Mechanism, Evidence Tier, Molecular Identity, And Pharmacokinetics For Qualified Researchers. For In Vitro Laboratory Research Use Only. Not Medical Advice Or Dosing Guidance.
Side-By-Side Comparison
| MOTS-c | AOD9604 | |
|---|---|---|
| Category | Weight Loss & Metabolism | Weight Loss & Metabolism |
| Compound Class | Mitochondrial-derived peptide (MDP) encoded within 12S rRNA of mitochondrial genome | Modified C-terminal growth-hormone fragment (hGH 177-191) |
| Evidence Tier | Research Compound | Research Compound |
| Molecular Target | AMPK activation; folate-methionine cycle; AICAR-independent AMPK signaling; nuclear translocation for gene expression regulation | Lipolysis via beta-3 adrenergic and lipase pathways; no GH receptor binding; no IGF-1 elevation |
| Molecular Weight | 2174.6 Da | 1815.1 Da |
| Amino Acid Sequence | MRWQEMGYIFYPRKLR | GH 176-191 with N-terminal Tyr (16 aa) |
| CAS Number | 1627580-64-6 | 221231-10-3 |
| Half-Life | ~30 minutes | ~3 minutes |
| Studied For | Metabolic homeostasis, Insulin resistance / obesity, Exercise-mimetic research, AMPK activation | Obesity / fat-metabolism research, Lipolysis / fat burning, Adipose tissue reduction, Body fat reduction without IGF-1 elevation |
About MOTS-c
A mitochondrial exercise-mimetic peptide; banned in sport since 2024, mostly preclinical.
Read The Full MOTS-c MonographAbout AOD9604
A growth-hormone fragment for fat loss that failed its key human trial; banned in sport.
Read The Full AOD9604 MonographKey Differences
- Reported half-life differs: MOTS-c at ~30 minutes versus AOD9604 at ~3 minutes.
- Primary molecular target differs: MOTS-c acts on AMPK activation; folate-methionine cycle; AICAR-independent AMPK signaling; nuclear translocation for gene expression regulation; AOD9604 acts on Lipolysis via beta-3 adrenergic and lipase pathways; no GH receptor binding; no IGF-1 elevation.
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This Comparison Is Provided For In Vitro Laboratory Research Use Only. Not For Human Consumption, Diagnosis, Or Treatment. See The Full Research Disclaimer.