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Select Up To Four Compounds To Review Their Evidence, Targets, And Handling Side By Side.
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| Attribute | ||
|---|---|---|
Research Summary | Selank acts like a calming blanket for a stressed-out brain. It completely wipes away anxiety, stops racing thoughts, and helps you focus clearly without making you feel sleepy or tired. | Semax is like a heavy cup of coffee for your brain but without the jitters. Originally developed in Russia, it sharpens your focus, improves your memory, and protects your brain from stress. |
Studied For | Generalized anxiety disorder researchStress modulationCognition / attention / focusMemory enhancementAnxiety reduction without sedationBDNF upregulationSerotonin system modulationDopamine modulationGABAergic modulationImmune modulation via tuftsin analogAntidepressant researchAlcohol withdrawal researchADHD researchNootropic researchNeuroplasticityAdaptive stress responsestress reliefcognitive enhancementfocusanxiety reductiondepressionimmune modulationBDNF increase | Ischemic stroke recoveryCognition / memory enhancementOptic nerve disordersCNS disorders researchADHD researchBDNF upregulationNeuroprotectionAnxiety reductionDepression modelsTransient ischemic attack (TIA) modelsSerotonin upregulationDopamine enhancementFocus and attention researchImmune modulationMelanocortin system cognitive effectsNeurogenesis researchPost-stroke cognitive improvementbrain fogcognitive enhancementADHDstroke recoveryneuroprotectionmemory improvementBDNF increasefocus |
Research Areas | CognitiveImmuneSleep & Circadian | CognitiveImmuneLongevity |
Best Stacked With | semaxdsippinealonbac-water | selankpinealoncerebrolysinnad-plusbac-water |
Overview | ||
Category | Immunity & Wellness | Immunity & Wellness |
Compound Class | Synthetic heptapeptide anxiolytic / nootropic; tuftsin analog (Thr-Lys-Pro-Arg-Pro-Gly-Pro) | Synthetic heptapeptide analog of ACTH 4-7 with Pro-Gly-Pro extension; neuroprotective and nootropic |
Molecular Target | Enkephalinase inhibition; GABA-A receptor modulation; BDNF upregulation; serotonin/dopamine pathway; T-cell tuftsin receptor | Melanocortin receptors (MC2R/MC4R); BDNF/NGF upregulation; serotonin/dopamine axis; enkephalinase inhibition |
Aliases / AKA | TP-7Selank peptideThr-Lys-Pro-Arg-Pro-Gly-Pro tuftsin analogAnxiolytic peptideRussian anti-anxiety peptideTuftsin analog | Semax peptideACTH 4-7 PGPMet-Glu-His-Phe-Pro-Gly-ProSemax nasal sprayACTH analog nootropicHeptapeptide nootropic |
Parent Compound | Tuftsin analog | ACTH(4-10) fragment |
Molecular Weight | 751.88 Da | 813.9 Da |
Amino Acid Sequence | Thr-Lys-Pro-Arg-Pro-Gly-Pro | Met-Glu-His-Phe-Pro-Gly-Pro |
CAS Number | 129954-34-3 | 80714-61-0 |
Year Discovered | Not Listed | Not Listed |
Pro-Angiogenic | No | No |
GLP-1 Class | No | No |
Purity | Not Listed | Not Listed |
Identity | ||
Evidence Tier | ||
Risk Level | ||
PubMed Citations | 202 Good | 314 Good |
Clinical Trials | 22 Active | Not Listed |
Regulatory Status | Registered in Russia; not FDA or EMA approved. | Registered in Russia; not FDA or EMA approved. |
Evidence & Regulatory | ||
Half-Life | ~2 minutes | ~5 minutes |
Typical Frequency | Not Listed | Not Listed |
Administration Route | Injection Only | Injection Only |
Mechanism / PK | Not Listed | Not Listed |
Reported Findings | Russian studies report anxiolytic efficacy without sedation, dependence, or withdrawal. Largely single-lineage and preliminary; no large Western trials. | Russian use and studies report benefit in stroke and cognition. Animal data show neuroprotection and improved learning. Predominantly Russian-literature and preliminary. |
Side Effects Noted | Reported well tolerated; intranasal use may cause local nasal irritation. | Reported well tolerated; intranasal local irritation; limited independent adverse-event data. |
Warnings | Narrow, non-replicated evidence; registered as a medicine in Russia but not FDA or EMA approved. Research use only elsewhere. | Thin, geographically concentrated evidence; registered in Russia but not FDA or EMA approved. Research use only elsewhere. |
Pharmacology | ||
Form | lyophilized | lyophilized |
Diluent | bacteriostatic water | bacteriostatic water |
Storage Temp | frozen, dark | frozen, dark |
Light Sensitive | Yes | Yes |
Freeze / Thaw | avoid | avoid |
Handling Notes | Often studied as an intranasal formulation. | Often studied as an intranasal formulation. |
Reconstituted Shelf Life | 28 Days Refrigerated | 28 Days Refrigerated |
Handling & Storage | ||
Pep Nation Lab's comparison tool puts research-grade peptides and compounds head to head - mechanism of action, molecular target, evidence tier, molecular weight, sequence, half-life, and documented research focus - so qualified researchers can evaluate the differences that matter. Every data point is drawn from a referenced monograph. For in vitro laboratory research use only.
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Any research-grade compound in the library can be placed side by side - up to four at a time. The tool compares mechanism of action, molecular target, evidence tier, molecular weight, amino acid sequence, reported half-life, and what each compound has been studied for, all drawn from referenced monographs.
The evidence tier reflects how extensively a compound has been studied in the referenced literature, from early preclinical signals through to compounds with human clinical data. It is a research-quality signal only, never a safety or efficacy endorsement.
Each comparison page is generated from the same referenced compound database - a genuine side-by-side of mechanism, identity, pharmacokinetics, and evidence, plus data-derived key differences. They are curated, not auto-generated thin pages.
No. Every comparison is for in vitro laboratory research use only. Nothing here is medical advice, a treatment recommendation, or dosing guidance, and no product is for human or animal consumption.
