What Can I Compare With The Pep Nation Lab Comparison Tool?

Any research-grade compound in the library can be placed side by side - up to four at a time. The tool compares mechanism of action, molecular target, evidence tier, molecular weight, amino acid sequence, reported half-life, and what each compound has been studied for, all drawn from referenced monographs.

What Does The Evidence Tier Mean?

The evidence tier reflects how extensively a compound has been studied in the referenced literature, from early preclinical signals through to compounds with human clinical data. It is a research-quality signal only, never a safety or efficacy endorsement.

How Are "X vs Y" Comparison Pages Built?

Each comparison page is generated from the same referenced compound database - a genuine side-by-side of mechanism, identity, pharmacokinetics, and evidence, plus data-derived key differences. They are curated, not auto-generated thin pages.

Is Any Of This Medical Or Dosing Advice?

No. Every comparison is for in vitro laboratory research use only. Nothing here is medical advice, a treatment recommendation, or dosing guidance, and no product is for human or animal consumption.

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Select Up To Four Compounds To Review Their Evidence, Targets, And Handling Side By Side.
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FOXO4-DRIB86

EpithalonB+91

Top Pick: EpithalonTap to see full verdict & analysis

FOXO4-DRI

0/100

Grade B

Leads in evidence strength

Evidence

Safety

Science

Coverage

Handling

Depth

Unique: Tissue Repair

Epithalon

0/100

Grade B+

Leads in safety profile

Evidence

Safety

Science

Coverage

Handling

Depth

Unique: Sleep & Circadian, Cognitive

Research Profile Radar - hover axes for details

FOXO4-DRI

Epithalon

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Attribute	FOXO4-DRI B	Epithalon B+
Research Summary	As you age, some of your cells turn into "zombies"—they stop working but refuse to die, and they make nearby cells sick. FOXO4-DRI is a sniper that hunts down these zombie cells and destroys them, leaving healthy cells alone.	Epithalon is an anti-aging master switch. Imagine your cells have little shoelace caps on their DNA that wear down as you get older. Epithalon rebuilds those caps, making old cells act young again.
Studied For	Senolytics / senescent cell clearanceAging / healthspan extensionChemotherapy-induced senescence reversalPhysical fitness restoration in aging modelsHair follicle rejuvenation in agingKidney function in aging modelsLiver health in agingInflammatory burden reductionSASP (senescence-associated secretory phenotype) suppressionp53-FOXO4 interaction disruptionApoptosis induction in senescent cellsAge-related tissue dysfunctionFrailty researchLongevity extension researchcellular senescencelongevityapoptosis of damaged cellshealthspan extensionhair regrowthfrailty	Telomere elongationAnti-aging / longevityCircadian rhythm regulationAntioxidant defenseMelatonin production stimulationPineal gland restorationImmune system enhancement in agingLifespan extension modelsCancer prevention researchDNA repairNeuroendocrine system regulationOxidative stress reductionAge-related disease preventionSleep quality via melatoninSkin anti-agingRetinal cell protectionInflammatory cytokine modulationlongevityanti-agingsleep regulationlife extensioncircadian rhythmmelatonin productiontelomere lengtheningantioxidant
Research Areas	LongevityImmuneTissue Repair	LongevityImmuneSleep & CircadianCognitive
Best Stacked With	epithalonnad-plusss-31thymalinbac-water	nad-plusss-31thymalinpinealonmelatoninbac-water
Overview
Category	Anti-Aging & Longevity	Anti-Aging & Longevity
Compound Class	D-retro-inverso peptide; protease-resistant cell-penetrating senolytic	Synthetic tetrapeptide bioregulator derived from pineal gland epithalamin
Molecular Target	FOXO4-p53 protein-protein interaction; disrupts pro-survival signaling in senescent cells, inducing selective apoptosis	Telomerase activation (TERT); pineal melatonin synthesis; antioxidant enzyme upregulation
Aliases / AKA	FOXO4 D-Retro-InversoFOXO4-DRI peptideFOXO4 DRIFOXO4 senolyticFOXO4-p53 disruptorSenolytic peptide	EpitalonEpithalaminAla-Glu-Asp-GlyAEDG peptideEpithalon tetrapeptidePineal peptide bioregulator
Parent Compound	FOXO4 transcription factor	Pineal extract epithalamin fragment
Molecular Weight	5223 Da	390.35 Da
Amino Acid Sequence	`~43-residue D-amino-acid retro-inverso FOXO4 analog`	`Ala-Glu-Asp-Gly (AEDG)`
CAS Number	not standardized	307297-39-8
Year Discovered	Not Listed	Not Listed
Pro-Angiogenic	No	No
GLP-1 Class	No	No
Purity	Not Listed	Not Listed
Identity
Evidence Tier
Risk Level
PubMed Citations	25 Sparse	217 Good
Clinical Trials	Not Listed	Not Listed
Regulatory Status	Not approved; investigational/research chemical.	Not FDA or EMA approved; research chemical only.
Evidence & Regulatory
Half-Life	~24-36 hours	~10-15 minutes
Typical Frequency	Not Listed	Not Listed
Administration Route	Injection Only	Injection Only
Mechanism / PK	Not Listed	Not Listed
Reported Findings	A landmark mouse study reported selective killing of senescent cells with restored fur, kidney function, and fitness in aged and progeroid mice. No human efficacy data exist. Preclinical only.	In vitro work in human fibroblasts reported induced telomerase activity and telomere elongation. Animal data show antioxidant and antitumor signals. Human evidence is limited, old, and from a single research group, so it is preliminary.
Side Effects Noted	No human safety data. As a p53-activating apoptosis inducer it carries theoretical off-target apoptosis and injection-site risks.	No well characterized adverse-event profile; reported well tolerated in sparse low-quality studies. Theoretical concern that telomerase upregulation could favor proliferation of malignant cells.
Warnings	Entirely preclinical; mechanism risk is uncharacterized in humans. Research use only.	Not approved anywhere; thin, non-independent human evidence. Research use only.
Pharmacology
Form	lyophilized	lyophilized
Diluent	sterile or bacteriostatic water	bacteriostatic or sterile water
Storage Temp	-20C frozen, dark	-20C frozen long-term, refrigerate after reconstitution
Light Sensitive	Yes	Yes
Freeze / Thaw	avoid	avoid
Handling Notes	D-retro-inverso design is unusually protease-resistant; can be less soluble.	Very short plasma half-life.
Reconstituted Shelf Life	28 Days Refrigerated	28 Days Refrigerated
Handling & Storage

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