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| Attribute | ||
|---|---|---|
Research Summary | Think of BPC-157 as the ultimate "Fix-It" mechanic for your body. Whether it is a torn muscle, a sore joint, or a damaged stomach, it rushes to the site and speeds up the healing process incredibly fast. | GHK-Cu is the ultimate beauty and repair signal. It grabs copper from your body and delivers it straight to your skin and hair, telling them to produce fresh, bouncy collagen and grow thicker hair. |
Studied For | GI mucosal healingTendon / ligament repairNerve repairAnti-inflammatoryGut health and integrityLeaky gut researchIBD / Crohn's disease modelsUlcerative colitis modelsGastric ulcer healingIntestinal anastomosis healingWound healing accelerationMuscle tear recoverySports injury recoveryJoint inflammation reductionBone healingCartilage repairNeurological recoverySpinal cord injury modelsPeripheral nerve regenerationAngiogenesis promotionBlood pressure regulationNitric oxide pathwayGrowth hormone receptor upregulationCytoprotectionSystemic healingNSAID-induced gastric damage reversalAlcohol-induced gut damage reversalPost-surgical healingScar reductionAnti-ulcer researchjoint healinggut healingtendon repairulcer repairligament healingmuscle tear recoveryleaky gutinflammation reductionpain reliefsoft tissue repair | Wound healingSkin anti-agingHair loss researchAntioxidant / anti-inflammatoryCollagen synthesis stimulationElastin productionGlycosaminoglycan synthesisDermal regenerationSkin tighteningWrinkle reductionMelanocyte stimulation / hair pigmentationScalp healthAlopecia modelsNerve regenerationLung tissue repairGI tract healingBone density supportAngiogenesisAntioxidant enzyme upregulationScar reductionSkin barrier restorationPost-procedure skin recoveryUV damage repair researchAnti-inflammatory skin researchskin tighteninganti-aginghair growthwrinkle repaircollagen productionscar reductionwound healingantioxidanttissue remodeling |
Research Areas | Healing & RecoveryTissue RepairGut Health & GI RepairPain & InflammationJoint & Bone SupportImmune | Skin & HairHealing & RecoveryTissue RepairJoint & Bone SupportImmune |
Best Stacked With | tb-500ghk-cukpvll-37bac-water | tb-500bpc-157ahk-cusnap-8epithalonbac-water |
Overview | ||
Category | Healing & Recovery | Skin, Hair & Cosmetics |
Compound Class | Synthetic pentadecapeptide derived from human gastric juice protein BPC | Naturally occurring copper-binding tripeptide (Gly-His-Lys + Cu2+) |
Molecular Target | NO-synthase, VEGF, FAK/paxillin, EGF receptor, growth hormone receptor; promotes angiogenesis, collagen synthesis, and cytoprotection | Extracellular matrix remodeling via MMP/TIMP balance; TGF-beta modulation; antioxidant enzyme (SOD, catalase) upregulation; VEGF and FGF stimulation |
Aliases / AKA | Body Protection Compound 157BPC157BPC 157BPC-157Pentadecapeptide BPC 157Stable Gastric Pentadecapeptide | Copper peptideGlycyl-L-histidyl-L-lysine copperGHK-CopperGHK CuCopper tripeptide-1Copper peptide GHK |
Parent Compound | Gastric juice BPC protein fragment | Plasma copper tripeptide |
Molecular Weight | 1419.5 Da | 340.85 Da |
Amino Acid Sequence | Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val | Gly-His-Lys + Cu(II) |
CAS Number | 137525-51-0 | 49557-75-7 (GHK-Cu complex) |
Year Discovered | Not Listed | Not Listed |
Pro-Angiogenic | Yes - Promotes New Vessel Growth | Yes - Promotes New Vessel Growth |
GLP-1 Class | No | No |
Purity | Not Listed | Not Listed |
Identity | ||
Evidence Tier | ||
Risk Level | ||
PubMed Citations | 224 Good | 127 Moderate |
Clinical Trials | 22 Active | 11 Active |
Regulatory Status | Not FDA-approved; under FDA compounding-safety review (503A bulk-substances evaluation); research chemical. | Cosmetic ingredient; injectable systemic use not approved. |
Evidence & Regulatory | ||
Half-Life | ~30 minutes | ~5-10 minutes |
Typical Frequency | Not Listed | Not Listed |
Administration Route | Injection Only | Injection Only |
Mechanism / PK | Not Listed | Not Listed |
Reported Findings | Evidence is overwhelmingly rodent and in vitro: accelerated healing, angiogenesis, and protection against NSAID gastrointestinal damage. Human evidence is very limited; injectable musculoskeletal claims are not established in humans. | Controlled cosmetic-dermatology studies report improved firmness and reduced fine lines from topical GHK-Cu, plus diabetic-ulcer and post-procedure healing. Systemic injectable human efficacy is not established. |
Side Effects Noted | Rodent toxicology is benign but human adverse-event data are essentially absent. FDA flags immunogenicity, unknown long-term effects, and a theoretical pro-angiogenic tumor-vascularization risk. | Topically well tolerated; possible local irritation; copper-overload is a theoretical concern with high or systemic exposure. |
Warnings | Not approved; flagged by the FDA under its 503A bulk-substances compounding-safety review. The pro-angiogenic mechanism is a theoretical concern in any malignancy. Research use only. | Recognized as a cosmetic ingredient, not a drug. Avoid co-layering with strong acids or high-dose vitamin C, which destabilize the copper complex. |
Pharmacology | ||
Form | lyophilized | lyophilized (blue copper complex) |
Diluent | bacteriostatic or sterile water; swirl, do not shake | sterile or bacteriostatic water |
Storage Temp | 2-8C; -20C long-term, dark | cold, dry, dark |
Light Sensitive | Yes | Yes |
Freeze / Thaw | avoid | avoid |
Handling Notes | Reported stable in gastric juice; arginate salt aids stability. | pH and redox sensitive. |
Reconstituted Shelf Life | 28 Days Refrigerated | 28 Days Refrigerated |
Handling & Storage | ||
Pep Nation Lab's comparison tool puts research-grade peptides and compounds head to head - mechanism of action, molecular target, evidence tier, molecular weight, sequence, half-life, and documented research focus - so qualified researchers can evaluate the differences that matter. Every data point is drawn from a referenced monograph. For in vitro laboratory research use only.
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Browse the full research catalog or the A To Z index to compare any compound.
Any research-grade compound in the library can be placed side by side - up to four at a time. The tool compares mechanism of action, molecular target, evidence tier, molecular weight, amino acid sequence, reported half-life, and what each compound has been studied for, all drawn from referenced monographs.
The evidence tier reflects how extensively a compound has been studied in the referenced literature, from early preclinical signals through to compounds with human clinical data. It is a research-quality signal only, never a safety or efficacy endorsement.
Each comparison page is generated from the same referenced compound database - a genuine side-by-side of mechanism, identity, pharmacokinetics, and evidence, plus data-derived key differences. They are curated, not auto-generated thin pages.
No. Every comparison is for in vitro laboratory research use only. Nothing here is medical advice, a treatment recommendation, or dosing guidance, and no product is for human or animal consumption.
