What Can I Compare With The Pep Nation Lab Comparison Tool?

Any research-grade compound in the library can be placed side by side - up to four at a time. The tool compares mechanism of action, molecular target, evidence tier, molecular weight, amino acid sequence, reported half-life, and what each compound has been studied for, all drawn from referenced monographs.

What Does The Evidence Tier Mean?

The evidence tier reflects how extensively a compound has been studied in the referenced literature, from early preclinical signals through to compounds with human clinical data. It is a research-quality signal only, never a safety or efficacy endorsement.

How Are "X vs Y" Comparison Pages Built?

Each comparison page is generated from the same referenced compound database - a genuine side-by-side of mechanism, identity, pharmacokinetics, and evidence, plus data-derived key differences. They are curated, not auto-generated thin pages.

Is Any Of This Medical Or Dosing Advice?

No. Every comparison is for in vitro laboratory research use only. Nothing here is medical advice, a treatment recommendation, or dosing guidance, and no product is for human or animal consumption.

Compare Compounds

Select Up To Four Compounds To Review Their Evidence, Targets, And Handling Side By Side.
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2/4

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AICARB-80

5-Amino-1MQB+89

Top Pick: 5-Amino-1MQTap to see full verdict & analysis

AICAR

0/100

Grade B-

Leads in data completeness

Evidence

Safety

Science

Coverage

Handling

Depth

5-Amino-1MQ

0/100

Grade B+

Leads in safety profile

Evidence

Safety

Science

Coverage

Handling

Depth

Unique: Weight Management & Fat Loss

Research Profile Radar - hover axes for details

AICAR

5-Amino-1MQ

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Attribute	AICAR B-	5-Amino-1MQ B+
Research Summary	AICAR tricks your body into thinking it just did a massive workout, even if it was just sitting still. It turns on your fat-burning mode and makes muscles act like they have been exercising for hours.	Imagine your cells have a tiny engine that burns fat, but sometimes a heavy brake gets stuck on it. 5-Amino-1MQ removes that brake so your cells can burn energy faster and shrink fat cells without you having to eat less.
Studied For	AMPK / metabolic-stress researchInsulin-resistance modelsEndurance researchExercise mimeticFat oxidation via AMPKGlucose uptake enhancementCardiac protection / ischemiaObesity modelsMetabolic syndrome researchWADA prohibited performance substance researchMitochondrial biogenesisType 2 diabetes modelsCancer metabolism researchAMPK pathway signalingAnti-inflammatory via AMPKendurance enhancementfat burningmetabolic regulatorischemic protectionmuscle metabolism	Obesity / metabolic syndromeFat-loss / energy-expenditure researchNAD+ metabolism enhancementNNMT inhibitionAdipogenesis inhibitionAdipocyte differentiation blockingLean mass preservationInsulin sensitivity improvementLipid metabolismDiet-induced obesity modelsWeight management without appetite suppressionSAM (S-adenosyl methionine) pool preservationEpigenetic metabolic regulationMitochondrial efficiencyExercise performancefat burningmetabolism boosterweight lossmuscle wasting preventioncellular energyanti-agingNAD+ salvage pathway
Research Areas	MetabolicPerformance & MuscleMitochondrial Function	MetabolicWeight Management & Fat LossMitochondrial FunctionPerformance & Muscle
Best Stacked With	mots-cnad-plusl-carnitinebac-water	nad-plusmots-cl-carnitinebac-water
Overview
Category	Weight Loss & Metabolism	Weight Loss & Metabolism
Compound Class	Purine nucleoside analog; cell-permeable AMPK activator (converted intracellularly to ZMP)	Small-molecule NNMT inhibitor (quinolinium salt); not a peptide
Molecular Target	AMP-activated protein kinase (AMPK) activation via ZMP (AMP mimetic); PGC-1alpha upregulation; GLUT4 translocation; mitochondrial biogenesis	Nicotinamide N-methyltransferase (NNMT) inhibition; preserves SAM and NAD+ pools; reduces adipogenesis; enhances energy expenditure
Aliases / AKA	AcadesineAICA-riboside5-aminoimidazole-4-carboxamide ribonucleotideAICAR nucleosideZMP precursorAcadesine AICAR	5-Amino-1-methylquinolinium5A1MQ5-amino-1-methylquinolinium saltNNMT inhibitor 5-amino-1mqNicotinamide N-methyltransferase inhibitor5-amino 1MQ
Parent Compound	ZMP precursor	1-methylnicotinamide mimic
Molecular Weight	258.23 Da	159.21 Da
Amino Acid Sequence	`small molecule nucleoside`	`small molecule (quinolinium)`
CAS Number	2627-69-2	685079-15-6 (iodide salt)
Year Discovered	Not Listed	Not Listed
Pro-Angiogenic	No	No
GLP-1 Class	No	No
Purity	Not Listed	Not Listed
Identity
Evidence Tier
Risk Level
PubMed Citations	2,818 Extensive	152 Moderate
Clinical Trials	Not Listed	Not Listed
Regulatory Status	Investigational / research chemical; WADA-prohibited at all times (metabolic modulator, AMPK activator).	Not approved; research chemical.
Evidence & Regulatory
Half-Life	~2 hours	~4 hours
Typical Frequency	Not Listed	Not Listed
Administration Route	Injection Only	Injection Only
Mechanism / PK	Not Listed	Not Listed
Reported Findings	Mostly in vitro and animal: increased glucose uptake, fat oxidation, and running endurance. Acadesine reached human cardiac-surgery trials but was never approved. No established human metabolic or performance efficacy.	Diet-induced-obese mice showed reduced body weight and fat mass without changed food intake. There are no completed published human trials; all claims are animal or in vitro. Preliminary.
Side Effects Noted	Transient hyperuricemia and headache in cardiac trials; broad AMPK activation can be context-dependently tumor-promoting; long-term human safety unknown.	No adverse effects in short rodent studies; essentially no human safety data; chronic effects on the methylation pool are uncharacterized.
Warnings	Investigational with no safe non-clinical dose. WADA-prohibited at all times (AMPK activator). Research use only.	Strictly investigational with no human approval and no defined human dose. CAS and salt form should be verified against a supplier certificate of analysis.
Pharmacology
Form	solid	solid (iodide salt)
Diluent	water or DMSO for stock	water or DMSO for stock
Storage Temp	cold, desiccated, dark	cold, desiccated, dark
Light Sensitive	Yes	Yes
Freeze / Thaw	avoid	avoid
Handling Notes	Use solutions fresh.	Prepare fresh.
Reconstituted Shelf Life	14 Days Refrigerated	28 Days Refrigerated
Handling & Storage

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