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Select Up To Four Compounds To Review Their Evidence, Targets, And Handling Side By Side.
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| Attribute | ||
|---|---|---|
Research Summary | Tirzepatide is a super-advanced weight loss signal. It acts like two different hormones combined into one, stopping your hunger completely while also making your body process sugars flawlessly. | Cagrilintide sends a powerful "I am totally full" signal to your brain. It acts just like a hormone your body makes when you eat a huge meal, making you feel satisfied and completely uninterested in food for a long time. |
Studied For | Type 2 diabetes managementChronic weight management / obesityObstructive sleep apnea in obesity (FDA approved 2024)Non-alcoholic fatty liver disease (NAFLD/MASH)Cardiovascular risk reductionHbA1c loweringBody weight reduction superior to semaglutideInsulin resistanceMetabolic syndromePolycystic ovary syndromeKidney disease in diabetesHeart failure with obesityAppetite suppression dual pathwayLean mass preservationweight lossdiabetesfat lossappetite suppressionobesitymetabolic syndromeinsulin sensitivityA1C reduction | Obesity / overweightType 2 diabetesCombination with semaglutide (CagriSema)Amylin receptor agonism for satietyCaloric intake reductionBody weight reductionGlucagon suppressionGastric emptying delayAmylin-mediated satiety signalingCardiometabolic risk reductionInsulin sensitivity improvementMetabolic syndromeweight losssatietyappetite suppressiongastric emptying slowingobesity |
Research Areas | MetabolicWeight Management & Fat Loss | MetabolicWeight Management & Fat Losshormonal |
Best Stacked With | l-carnitineb12lipo-cbac-water | semaglutidebac-water |
Overview | ||
Category | Weight Loss & Metabolism | Weight Loss & Metabolism |
Compound Class | Dual GIP/GLP-1 receptor co-agonist (twincretin); synthetic 39-residue peptide with C18 fatty diacid for albumin binding | Long-acting synthetic amylin analog (fatty acid-conjugated for once-weekly dosing) |
Molecular Target | GIPR (GIP receptor) + GLP-1R (GLP-1 receptor); dual incretin axis activation; pancreatic insulin secretion and hypothalamic appetite suppression | Amylin receptor (AMY1-3, CTR + RAMP1/2/3 complexes) and calcitonin receptor (CTR); hypothalamic satiety signaling; gastric motility modulation |
Aliases / AKA | MounjaroZepboundLY3298176Tirzepatide peptideGIP GLP-1 dual agonistEli Lilly dual agonist | AM833Cagrilintide AM833Long-acting amylin analogAmylin receptor agonistCalcitonin receptor agonist obesityAmylin obesity peptide |
Parent Compound | Incretin dual agonist | Human amylin |
Molecular Weight | 4813.45 Da | 4409.01 Da |
Amino Acid Sequence | 39-aa acylated peptide (C20 diacid) | acylated cyclic amylin analog |
CAS Number | 2023788-19-2 | 1415456-99-3 |
Year Discovered | Not Listed | Not Listed |
Pro-Angiogenic | No | No |
GLP-1 Class | No | |
Purity | Not Listed | Not Listed |
Identity | ||
Evidence Tier | ||
Risk Level | ||
PubMed Citations | 2,193 Extensive | 80 Moderate |
Clinical Trials | 174174 Active | 2222 Active |
Regulatory Status | FDA-approved; compounded versions are not FDA-evaluated. | Investigational (Novo Nordisk); not FDA-approved. |
Evidence & Regulatory | ||
Half-Life | ~1 week | ~1 week (weekly SC, acylated) |
Typical Frequency | Not Listed | Not Listed |
Administration Route | Injection Only | Injection Only |
Mechanism / PK | Not Listed | Not Listed |
Reported Findings | Strong human trials (SURPASS, SURMOUNT), superior to semaglutide on weight in a head-to-head; FDA-approved for diabetes, obesity, and sleep apnea. | A Phase 2 dose-finding trial showed roughly 10.8 percent weight reduction at 26 weeks with the highest dose versus about 3 percent for placebo; development is most advanced in combination with semaglutide. |
Side Effects Noted | Dose-dependent gastrointestinal effects; gallbladder and pancreatitis signals. | Predominantly gastrointestinal effects (nausea, vomiting), mild to moderate and dose-dependent; injection-site reactions. |
Warnings | FDA boxed warning for thyroid C-cell tumors; contraindicated with personal or family medullary thyroid carcinoma or MEN 2. Approved product is distinct from compounded versions. | Investigational with no approved indication; long-term safety not established. Research use only. |
Pharmacology | ||
Form | lyophilized (research) or pen/vial | lyophilized |
Diluent | bacteriostatic water | bacteriostatic or sterile water |
Storage Temp | Refrigerate 2-8°C | frozen/refrigerated, dark |
Light Sensitive | Yes | Yes |
Freeze / Thaw | avoid | avoid |
Handling Notes | Avoid freeze-thaw, heat, and shaking. | Cyclic disulfide; avoid reducing conditions. |
Reconstituted Shelf Life | 28 Days Refrigerated | 28 Days Refrigerated |
Handling & Storage | ||
Pep Nation Lab's comparison tool puts research-grade peptides and compounds head to head - mechanism of action, molecular target, evidence tier, molecular weight, sequence, half-life, and documented research focus - so qualified researchers can evaluate the differences that matter. Every data point is drawn from a referenced monograph. For in vitro laboratory research use only.
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Single GLP-1 versus dual GLP-1/GIP incretin agonists in metabolic research.
Dual versus triple incretin receptor agonists in weight-research models.
A GLP-1 agonist versus a triple-agonist incretin in metabolic research.
A GHRH analog versus a selective ghrelin-receptor secretagogue.
A ghrelin-receptor secretagogue versus a GHRH analog for growth-hormone research.
Two GHRH analogs studied on the growth-hormone axis.
The two first-generation growth-hormone releasing peptides.
An amylin analog versus a GLP-1 agonist in metabolic research.
A mitochondrial-derived peptide versus an HGH fragment in metabolic research.
Melanocortin versus kisspeptin pathways in reproductive research.
A telomerase-pathway peptide versus NAD+ metabolism in longevity research.
A potent versus a highly selective ghrelin-receptor secretagogue.
Two GHRH analogs with contrasting half-life profiles.
A direct IGF-1 analog versus a growth-hormone secretagogue.
The DAC versus non-DAC forms of the CJC-1295 GHRH analog.
Two Russian-developed nootropic and anxiolytic research peptides.
Two mitochondrial-targeted peptides in cellular-energy research.
Two immune-modulating research peptides with distinct mechanisms.
Two HGH-fragment analogs studied for fat-metabolism research.
Next-generation multi-receptor incretin agonists in metabolic research.
Two leading tissue-repair peptides with distinct healing mechanisms.
A systemic repair peptide versus a copper peptide for tissue and skin research.
A GHRH analog versus a selective ghrelin-receptor secretagogue on the GH axis.
A dual incretin agonist versus an amylin analog in metabolic research.
A triple incretin agonist versus an amylin analog in weight research.
Two metabolic research compounds targeting mitochondrial and NNMT pathways.
NAD+ metabolism versus a mitochondrial-derived peptide in longevity research.
Two copper research peptides studied for skin and hair.
A long-acting versus a short-acting GHRH analog.
A selective versus a first-generation ghrelin-receptor secretagogue.
A GLP-1 agonist versus a GLP-1/amylin combination in metabolic research.
Two peptides studied for gut and mucosal repair.
Melanocortin versus oxytocin pathways in intimacy and libido research.
Two thymic immune-modulating research peptides.
An anxiolytic nootropic versus a sleep-associated research peptide.
Direct IGF-1 signaling versus myostatin inhibition in muscle research.
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Browse the full research catalog or the A To Z index to compare any compound.
Any research-grade compound in the library can be placed side by side - up to four at a time. The tool compares mechanism of action, molecular target, evidence tier, molecular weight, amino acid sequence, reported half-life, and what each compound has been studied for, all drawn from referenced monographs.
The evidence tier reflects how extensively a compound has been studied in the referenced literature, from early preclinical signals through to compounds with human clinical data. It is a research-quality signal only, never a safety or efficacy endorsement.
Each comparison page is generated from the same referenced compound database - a genuine side-by-side of mechanism, identity, pharmacokinetics, and evidence, plus data-derived key differences. They are curated, not auto-generated thin pages.
No. Every comparison is for in vitro laboratory research use only. Nothing here is medical advice, a treatment recommendation, or dosing guidance, and no product is for human or animal consumption.
