HMG
Also Known As: Human Menopausal Gonadotropin, Menotropin, Menopur, Repronex, Pergonal, Humegon, Menogon, FSH LH blend, HMG injection, Gonadotropin blend, FSH/LH combination, Urinary gonadotropin extract, HMG fertility drug, menotropins
HMG is a research-grade Purified urinary extract containing FSH + LH gonadotropins targeting FSH receptor studied in Muscle Growth & Performance research. It is supplied strictly for in vitro laboratory research use only - not for human or animal consumption, and not FDA-approved.
Evidence Tier: Approved Drug - FDA and/or EMA approved with robust human trial data.
An approved fertility gonadotropin; prohibited in males in sport.
At A Glance
| Category | Muscle Growth & Performance |
|---|---|
| Compound Class | Purified urinary extract containing FSH + LH gonadotropins |
| Molecular Target | FSH receptor (FSHR) on granulosa/Sertoli cells + LH/hCG receptor (LHCGR) on theca/Leydig cells; dual gonadal stimulation |
| Molecular Weight | mixture (~30 kDa subunits) |
| Amino Acid Sequence | glycoprotein hormone mixture |
| CAS Number | 9002-68-0 |
| Half-Life | ~11-23 hours |
| WADA Status | prohibited_males |
| Evidence Tier | Approved Drug |
Mechanism Of Action
It provides a mix of FSH and LH, the two master hormones that directly command the reproductive organs to produce viable sperm cells or mature eggs.
Studied For
- IVF / ART ovulation induction
- Controlled ovarian hyperstimulation
- Spermatogenesis support in males
- Hypogonadotropic hypogonadism
- Female infertility treatment
- Male infertility research
- Follicle development
- Polycystic ovary syndrome (PCOS) research
- LH + FSH combined stimulation
- Fertility preservation research
- Assisted reproduction research
- fertility
- spermatogenesis
- LH/FSH
- FSH
- testicular function
Reported Research Findings
Established human use for follicular recruitment and ovulation induction; comparable live-birth outcomes to recombinant FSH.
Safety And Handling Notes
Ovarian hyperstimulation syndrome, multiple pregnancy, injection-site reactions, abdominal bloating; rare thromboembolism.
Contraindicated in primary ovarian or testicular failure and hormone-dependent tumors; requires monitoring for hyperstimulation. WADA-prohibited in males.
Regulatory Status
FDA/EMA-approved Rx; WADA-prohibited in males.
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Maintained By The Pep Nation Lab Research Team. See Our Editorial Standards And Research Methodology For How This Reference Is Sourced And Reviewed.
This Reference Is Provided For In Vitro Laboratory Research Use Only. Not For Human Consumption. See The Full Research Disclaimer.