Technical Data Sheet

MOTS-c

Also Known As: Mitochondrial ORF of 12S rRNA type-c, MOTS c, MOTS-c peptide, Mitochondrial peptide MOTS-c, Mitokine MOTS-c, 12S rRNA-encoded peptide, Exercise mimetic peptide, Mitochondrial-derived peptide, Metabolic MOTS-c, MRFA16 peptide analog, mitochondrial peptide, exercise mimetic, MOTSc

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Evidence Tier	Research Compound
Category	Weight Loss & Metabolism
Class	Mitochondrial-derived peptide (MDP) encoded within 12S rRNA of mitochondrial genome
Molecular Target	AMPK activation; folate-methionine cycle; AICAR-independent AMPK signaling; nuclear translocation for gene expression regulation
Sequence	MRWQEMGYIFYPRKLR
Molecular Weight	~2174 g/mol
CAS	1627580-64-6
Parent	Mitochondrial MT-RNR1
Mechanism	It acts directly on the mitochondria (the cell's engine) and activates the AMPK pathway, which shifts the body from storing fat to rapidly burning glucose and fatty acids for athletic endurance.
Studied For	Metabolic homeostasis, Insulin resistance / obesity, Exercise-mimetic research, AMPK activation, Glucose metabolism, Skeletal muscle uptake, Longevity and aging, Inflammation regulation, Mitochondrial stress response, Obesity research, Type 2 diabetes models, Menopause-related metabolic changes, NAD metabolism, Folate-methionine cycle, Mitochondrial communication, Physical endurance research, Metabolic flexibility, metabolic regulation, energy boost, AMPK activator, weight loss, insulin sensitivity, exercise endurance, mitochondrial function
Administration Route	Injection Only
Form	lyophilized
Diluent	bacteriostatic or sterile water
Storage Temperature	frozen/refrigerated, dark
Light Sensitive	Yes
Freeze / Thaw	avoid
Reconstituted Shelf Life	28 Days
Handling Notes	Two methionines are oxidation-prone.
Regulatory	Not FDA-approved; research chemical. Named on the WADA 2026 Prohibited List under S4.4.1 as "mitochondrial open reading frame of the 12S rRNA-c (MOTS-c)", an AMPK activator; prohibited at all times and a non-Specified substance.
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