Technical Data Sheet

AICAR

Also Known As: Acadesine, AICA-riboside, 5-aminoimidazole-4-carboxamide ribonucleotide, AICAR nucleoside, ZMP precursor, Acadesine AICAR, AMPK activator AICAR, Exercise mimetic AICAR, Metabolic research AICAR, AICA ribonucleoside, Purine nucleoside analog AICAR, AMPK activator, exercise in a bottle, acadesine, ZMP

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Evidence Tier	Research Compound
Category	Weight Loss & Metabolism
Class	Purine nucleoside analog; cell-permeable AMPK activator (converted intracellularly to ZMP)
Molecular Target	AMP-activated protein kinase (AMPK) activation via ZMP (AMP mimetic); PGC-1alpha upregulation; GLUT4 translocation; mitochondrial biogenesis
Sequence	small molecule nucleoside
Molecular Weight	~258 g/mol
CAS	2627-69-2
Parent	ZMP precursor
Mechanism	It enters your cells and flips a master energy switch called AMPK. When this switch is flipped, the cell starts burning fat for energy and builds more stamina engines (mitochondria).
Studied For	AMPK / metabolic-stress research, Insulin-resistance models, Endurance research, Exercise mimetic, Fat oxidation via AMPK, Glucose uptake enhancement, Cardiac protection / ischemia, Obesity models, Metabolic syndrome research, WADA prohibited performance substance research, Mitochondrial biogenesis, Type 2 diabetes models, Cancer metabolism research, AMPK pathway signaling, Anti-inflammatory via AMPK, endurance enhancement, fat burning, metabolic regulator, ischemic protection, muscle metabolism
Administration Route	Injection Only
Form	solid
Diluent	water or DMSO for stock
Storage Temperature	cold, desiccated, dark
Light Sensitive	Yes
Freeze / Thaw	avoid
Reconstituted Shelf Life	14 Days
Handling Notes	Use solutions fresh.
Regulatory	Investigational / research chemical; not DEA-controlled. Named on the WADA 2026 Prohibited List under S4.4.1 (activators of the AMP-activated protein kinase); prohibited at all times and a non-Specified substance.
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