Technical Data Sheet
TB-500 / Thymosin Beta-4
Also Known As: TB500, TB-500, Thymosin Beta-4, Tbeta4, Thymosin B4 Acetate, Thymosin β-4, TB-4, Tβ4, Thymosin Beta 4, T-beta4, Actin-sequestering peptide, Wound healing thymosin, Cardiac repair thymosin, LKKTETQ peptide motif, Thymosin beta4 synthetic, TB500 injection, thymosin beta 4, TB 500
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| Evidence Tier | Research Compound |
|---|---|
| Category | Healing & Recovery |
| Class | Endogenous 43-amino acid thymic peptide; G-actin sequestrant and tissue-protection factor |
| Molecular Target | G-actin sequestration (Wiskott-Aldrich Syndrome protein WH2 domain); VEGF upregulation; integrin-linked kinase (ILK); thymosin beta-4 receptor (Tβ4R) |
| Sequence | full Tbeta4 43 aa; TB-500 marketed fragment Ac-LKKTETQ |
| Molecular Weight | Tbeta4 ~4921 Da; fragment ~889 Da |
| CAS | 77591-33-4 (Tbeta4) |
| Parent | Thymosin beta-4 |
| Mechanism | It binds to cellular actin, the protein responsible for cell movement. This heavily upregulates cell migration, allowing healing cells to travel quickly into damaged soft tissue to begin structural repair. |
| Studied For | Dermal / corneal wound healing, Cardiac repair models, Tendon / ligament / muscle injury, Hair growth stimulation, Corneal healing / dry eye models, Blood vessel formation, Angiogenesis, Bone repair, Anti-inflammatory, Nerve repair models, Sports injury recovery, Athletic recovery, Post-surgical healing, Scar tissue reduction, Joint repair, Muscle tear recovery, GI healing, Immune modulation, Stem cell migration, muscle recovery, cardiac repair, wound healing, equine recovery, tissue regeneration, anti-inflammatory, flexibility, hair growth, stem cell migration |
| Administration Route | Injection Only |
| Form | lyophilized |
| Diluent | bacteriostatic or sterile water; swirl |
| Storage Temperature | cold, dark; frozen long-term |
| Light Sensitive | Yes |
| Freeze / Thaw | avoid |
| Reconstituted Shelf Life | 28 Days |
| Handling Notes | Verify identity; labeling often mismatches. |
| Regulatory | Not FDA-approved. Named on the WADA 2026 Prohibited List under S2.3 as "Thymosin-beta4 and its derivatives e.g. TB-500"; prohibited at all times and a non-Specified substance. |
| Sources |