Technical Data Sheet
Semax
Also Known As: Semax peptide, ACTH 4-7 PGP, Met-Glu-His-Phe-Pro-Gly-Pro, Semax nasal spray, ACTH analog nootropic, Heptapeptide nootropic, Russian nootropic peptide, Pro-Gly-Pro analog ACTH, Semax cognitive peptide, Semax neuroprotective, N-acetylated Semax, Semax 0.1% nasal, Semax 1% nasal, nootropic, ACTH analog, brain peptide
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| Evidence Tier | Research Compound |
|---|---|
| Category | Immunity & Wellness |
| Class | Synthetic heptapeptide analog of ACTH 4-7 with Pro-Gly-Pro extension; neuroprotective and nootropic |
| Molecular Target | Melanocortin receptors (MC2R/MC4R); BDNF/NGF upregulation; serotonin/dopamine axis; enkephalinase inhibition |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
| Molecular Weight | ~813 Da |
| CAS | 80714-61-0 |
| Parent | ACTH(4-10) fragment |
| Mechanism | It stimulates the rapid release of Brain-Derived Neurotrophic Factor (BDNF), which encourages neurons to form new connections, dramatically improving learning capacity and mental stamina. |
| Studied For | Ischemic stroke recovery, Cognition / memory enhancement, Optic nerve disorders, CNS disorders research, ADHD research, BDNF upregulation, Neuroprotection, Anxiety reduction, Depression models, Transient ischemic attack (TIA) models, Serotonin upregulation, Dopamine enhancement, Focus and attention research, Immune modulation, Melanocortin system cognitive effects, Neurogenesis research, Post-stroke cognitive improvement, brain fog, cognitive enhancement, ADHD, stroke recovery, neuroprotection, memory improvement, BDNF increase, focus |
| Administration Route | Injection Only |
| Form | lyophilized |
| Diluent | bacteriostatic water |
| Storage Temperature | frozen, dark |
| Light Sensitive | Yes |
| Freeze / Thaw | avoid |
| Reconstituted Shelf Life | 28 Days |
| Handling Notes | Often studied as an intranasal formulation. |
| Regulatory | Registered in Russia; not FDA or EMA approved. |
| Sources |