Technical Data Sheet
KPV
Also Known As: Lys-Pro-Val, Alpha-MSH tripeptide core, MSH fragment, KPV peptide, Alpha-melanocyte-stimulating hormone C-terminal tripeptide, Anti-inflammatory tripeptide, GI anti-inflammatory peptide, MSH-derived tripeptide, KPV tripeptide, Immunomodulatory tripeptide, IBD peptide research, Mucosal healing peptide, alpha-MSH fragment
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| Evidence Tier | Research Compound |
|---|---|
| Category | Healing & Recovery |
| Class | Tripeptide C-terminal fragment of alpha-MSH (melanocyte-stimulating hormone) |
| Molecular Target | MC1R / melanocortin receptors; NF-kB inhibition; reduces TNF-alpha, IL-1beta, IL-6 production; mucosal protection |
| Sequence | Lys-Pro-Val |
| Molecular Weight | ~342.4 Da |
| CAS | 67727-97-3 |
| Parent | alpha-MSH C-terminal fragment |
| Mechanism | It enters inside the cell and directly blocks a molecule (NF-kB) that acts as the main "fire alarm" for inflammation. Once blocked, the cell stops producing inflammatory chemicals. |
| Studied For | GI inflammation / IBD research, Ulcerative colitis models, Crohn's disease models, Skin inflammation, Wound healing, Immune modulation, NF-kB pathway inhibition, Anti-inflammatory cytokine reduction, Mucosal barrier integrity, Gut health restoration, Psoriasis research, Eczema research, Colitis models, Melanocortin receptor anti-inflammatory, Systemic inflammation reduction, Oral peptide delivery research, anti-inflammatory, gut healing, Candida, IBD, psoriasis, mast cell stabilization, skin healing, ulcerative colitis |
| Administration Route | Injection Only |
| Form | lyophilized |
| Diluent | sterile or bacteriostatic water |
| Storage Temperature | cold, dry |
| Light Sensitive | Yes |
| Freeze / Thaw | avoid |
| Reconstituted Shelf Life | 28 Days |
| Handling Notes | Small, relatively stable tripeptide. |
| Regulatory | Not FDA-approved; research chemical. |
| Sources |