Technical Data Sheet

IGF-1 LR3

Also Known As: Long-Arg3 IGF-I, Insulin-like Growth Factor 1 LR3, IGF1 LR3, IGF-1 LR3, Long R3 IGF-1, Long R3 insulin-like growth factor, IGF LR3, LR3 IGF-1, Des(1-3)-IGF-1 long analog, IGF1-LR3 recombinant, Anabolic growth factor peptide, Muscle growth factor IGF, Somatomedin C analog, Insulin-like Growth Factor 1 Long Arg3, IGF1-LR3

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Evidence Tier	Research Compound
Category	Muscle Growth & Performance
Class	Long-acting recombinant IGF-1 analog (Arg3 substitution, 13 N-terminal extension)
Molecular Target	IGF-1 receptor (IGF1R); PI3K/Akt/mTOR signaling; satellite cell proliferation; reduced IGFBP binding = extended half-life
Sequence	83-aa analog (Arg3 + N-terminal extension)
Molecular Weight	~9.1 kDa
CAS	946870-92-4
Parent	Insulin-like growth factor 1
Mechanism	It binds to receptors that trigger massive cell division and growth in muscle tissue. The LR3 modification prevents it from being deactivated by blood proteins, extending its active life from minutes to over 20 hours.
Studied For	Muscle growth / hypertrophy, Anabolic research, GH axis signaling, Lean mass increase, Satellite cell activation, Muscle protein synthesis, Anti-catabolic research, Fat loss via anabolic signaling, Bone density support, Tendon collagen synthesis, Nerve growth and repair, Cartilage repair, Glucose uptake / insulin sensitivity, Cell proliferation research, GH-independent anabolic pathway, Recovery and repair acceleration, Body recomposition research, muscle hyperplasia, site enhancement, anabolic, muscle growth, recovery, anti-aging
Administration Route	Injection Only
Form	lyophilized
Diluent	dilute acetic acid or sterile/bacteriostatic water per supplier
Storage Temperature	-4°F, dark
Light Sensitive	Yes
Freeze / Thaw	avoid
Reconstituted Shelf Life	14 Days
Handling Notes	Aliquot and freeze for longer storage.
Regulatory	Not FDA-approved for humans (distinct from approved mecasermin); research/cell-culture reagent; WADA S2.
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