Technical Data Sheet
GHK-Cu
Also Known As: Copper peptide, Glycyl-L-histidyl-L-lysine copper, GHK-Copper, GHK Cu, Copper tripeptide-1, Copper peptide GHK, Lamin, Iamin, Tricomin, Folligen, Skin copper peptide, GHK cupric complex, CuGHK, Glycyl histidyl lysine, Collaxyl, Copper peptide serum, copper peptide, GHK copper, blue peptide, wrinkles
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| Evidence Tier | Cosmetic |
|---|---|
| Category | Skin, Hair & Cosmetics |
| Class | Naturally occurring copper-binding tripeptide (Gly-His-Lys + Cu2+) |
| Molecular Target | Extracellular matrix remodeling via MMP/TIMP balance; TGF-beta modulation; antioxidant enzyme (SOD, catalase) upregulation; VEGF and FGF stimulation |
| Sequence | Gly-His-Lys + Cu(II) |
| Molecular Weight | ~402 Da (copper complex) |
| CAS | 49557-75-7 (GHK-Cu complex) |
| Parent | Plasma copper tripeptide |
| Mechanism | It physically attaches to copper molecules and pulls them into your cells. Once inside, it flips on the genes responsible for making collagen and turns off the genes that cause inflammation and scarring. |
| Studied For | Wound healing, Skin anti-aging, Hair loss research, Antioxidant / anti-inflammatory, Collagen synthesis stimulation, Elastin production, Glycosaminoglycan synthesis, Dermal regeneration, Skin tightening, Wrinkle reduction, Melanocyte stimulation / hair pigmentation, Scalp health, Alopecia models, Nerve regeneration, Lung tissue repair, GI tract healing, Bone density support, Angiogenesis, Antioxidant enzyme upregulation, Scar reduction, Skin barrier restoration, Post-procedure skin recovery, UV damage repair research, Anti-inflammatory skin research, skin tightening, anti-aging, hair growth, wrinkle repair, collagen production, scar reduction, wound healing, antioxidant, tissue remodeling |
| Administration Route | Injection Only |
| Form | lyophilized (blue copper complex) |
| Diluent | sterile or bacteriostatic water |
| Storage Temperature | cold, dry, dark |
| Light Sensitive | Yes |
| Freeze / Thaw | avoid |
| Reconstituted Shelf Life | 28 Days |
| Handling Notes | pH and redox sensitive. |
| Regulatory | Cosmetic ingredient; injectable systemic use not approved. |
| Sources |