Technical Data Sheet

FOXO4-DRI

Also Known As: FOXO4 D-Retro-Inverso, FOXO4-DRI peptide, FOXO4 DRI, FOXO4 senolytic, FOXO4-p53 disruptor, Senolytic peptide, D-retro-inverso FOXO4, Senescent cell clearance peptide, FOXO4 peptide, Anti-senescence peptide, Healthspan peptide, Age reversal peptide, senolytic, anti-aging, proxofim

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Evidence Tier	Preclinical
Category	Anti-Aging & Longevity
Class	D-retro-inverso peptide; protease-resistant cell-penetrating senolytic
Molecular Target	FOXO4-p53 protein-protein interaction; disrupts pro-survival signaling in senescent cells, inducing selective apoptosis
Sequence	~43-residue D-amino-acid retro-inverso FOXO4 analog
Molecular Weight	~5 kDa
CAS	not standardized
Parent	FOXO4 transcription factor
Mechanism	It breaks the lock that zombie (senescent) cells use to keep themselves alive. Once the lock is broken, the zombie cell undergoes natural self-destruction (apoptosis), clearing the way for fresh cells.
Studied For	Senolytics / senescent cell clearance, Aging / healthspan extension, Chemotherapy-induced senescence reversal, Physical fitness restoration in aging models, Hair follicle rejuvenation in aging, Kidney function in aging models, Liver health in aging, Inflammatory burden reduction, SASP (senescence-associated secretory phenotype) suppression, p53-FOXO4 interaction disruption, Apoptosis induction in senescent cells, Age-related tissue dysfunction, Frailty research, Longevity extension research, cellular senescence, longevity, apoptosis of damaged cells, healthspan extension, hair regrowth, frailty
Administration Route	Injection Only
Form	lyophilized
Diluent	sterile or bacteriostatic water
Storage Temperature	-4°F frozen, dark
Light Sensitive	Yes
Freeze / Thaw	avoid
Reconstituted Shelf Life	28 Days
Handling Notes	D-retro-inverso design is unusually protease-resistant; can be less soluble.
Regulatory	Not approved; investigational/research chemical.
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