Sleep & Circadian

Overview

Sleep peptide research focuses on regulators of circadian rhythm, slow-wave sleep architecture, and the pineal melatonin system. The category combines well-characterized endocrine agents (melatonin, FDA-recognized as a dietary supplement and prescription in some jurisdictions), the investigational delta-sleep-inducing peptide DSIP, the Khavinson pineal bioregulator epithalon, and indirect sleep modulators including GH-axis agents that increase slow-wave sleep. Research-relevant endpoints include sleep-onset latency, slow-wave sleep duration, REM density, and morning cortisol patterns. Polysomnographic data are the gold standard; most peptide claims in this category rest on either small sleep-lab studies or extrapolation from circadian-rhythm and pineal-physiology mechanisms.