Longevity

Overview

Longevity peptide research examines compounds that target the hallmarks of aging: cellular senescence, telomere attrition, mitochondrial dysfunction, and loss of proteostasis. The category spans the Khavinson bioregulators (epithalon, pinealon, thymalin), the senolytic FOXO4-DRI, mitochondrial-targeting SS-31, and the NAD-precursor and antioxidant cofactor space (NAD+, glutathione). A central scientific tension in this category is the divergence between mechanistically grounded preclinical results and the scarcity of controlled long-term human data. Most geroprotector peptides have no randomized controlled trial powered for healthspan outcomes, and the Khavinson cohort studies are decades old and have not been independently replicated.