Gut Health & GI Repair
Mucosal repair, tight-junction integrity, and GI cytoprotection literature (BPC-157, KPV, VIP).
Overview
Gut-health peptide research investigates compounds that restore mucosal barrier integrity, reduce intestinal inflammation, and modulate the enteric nervous system. BPC-157 is the most-studied agent: derived from a partial sequence of body-protective compound in human gastric juice, it shows reproducible cytoprotection across rodent gastrointestinal injury models including NSAID-induced ulceration, esophagitis, and inflammatory-bowel-disease analogs. KPV (the C-terminal tripeptide of alpha-MSH) shows anti-inflammatory activity in colitis models via PepT1-mediated mucosal uptake and downstream melanocortin signaling. VIP modulates enteric neuro-immune crosstalk, and LL-37 contributes to mucosal antimicrobial defense. Together, these agents target the tight junctions, mucosal immune cells, and enteric neurons that together define gut barrier function.
Biological Pathways
BPC-157
Popular Name: Body Protection Compound 157, BPC157, BPC 157
$XX.XX
GHRP-6
Popular Name: GHRP6, Growth Hormone Releasing Hexapeptide, GHRP-6 peptide
$XX.XX
KLOW
Popular Name: KLOW stack, TB10 BPC10 GHK50 KPV10, KLOW blend
$XX.XX
KPV
Popular Name: Lys-Pro-Val, Alpha-MSH tripeptide core, MSH fragment
$XX.XX
LL-37
Popular Name: Cathelicidin, hCAP-18 fragment, CAP-18
$XX.XX
Thymosin Alpha-1
Popular Name: Thymalfasin, Zadaxin, Talpha1
$XX.XX